Compare Risperdal vs. Rexulti

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Risperdal (risperidone)

Prescription only

Rexulti (brexpiprazole)

Prescription only
Helps control your thoughts and mood.

Risperdal (risperidone) is an effective medication in treating schizophrenia, mania, and irritability associated with autism; however, amongst other newer medications in its class, it's more likely to cause side effects, such weight gain and hormone problems.

3.4/ 5 average rating with 45 reviewsforRisperdal
Helps improve your mood and control your thoughts.

Rexulti (brexpiprazole) is an option for people with depression or schizophrenia but it can be more expensive than other medicines.

Upsides
  • Risperdal (risperidone) is effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior. It also lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
  • Less likely to cause heart problems compared to other antipsychotics.
  • Compared to other antipsychotics, Risperdal (risperidone) causes less sedation and weight gain.
  • A generic version available for pill, dissolving tablet, and liquid formulations.
  • Rexulti (brexpiprazole) does not cause as much weight gain as other similar medications.
  • Fewer side effects compared to other similar medications.
Downsides
  • Mild to moderate risk of Extrapyramidal Symptoms (EPS) - movement disorders that cause stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • People taking Risperdal (risperidone) might have weight gain and problems with cholesterol or blood sugar.
  • Compared to other antipsychotics, this medication has a higher risk of hormone problems that can cause nipples to leak and male breasts to grow abnormally large.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • Risperdal (risperidone) takes 4 to 6 weeks for its full effects on thoughts and mood.
  • Avaliable only as brand name and can be more expensive than other options. However, there may be programs to help with co-pays.
  • Rexulti (brexpiprazole) can cause restlessness, especially when you take higher doses and after a long period of time.
  • Can increase your cholesterol, blood sugar, and cause weight gain.
  • Elderly patients with dementia should not take Rexulti (brexpiprazole).
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Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
  • Pill
Price
No pricing information available
Lowest price
$1157.45
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Reviews
45 reviews so far
42%
saidit'sworth it
47%
saiditworked well
49%
saidit'sa big hassle

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Side effects
23possible side effects
  • Sedation
    63%
  • Increased appetite
    44%
  • Fatigue
    31%
  • Vomiting
    20%
  • Common cold
    19%
  • Constipation
    17%
  • Cough
    17%
  • Fever
    16%
  • Involuntary urination
    16%
  • Drooling
    12%
  • Headache
    12%
  • Hay fever
    12%
  • Dry mouth
    10%
  • Nasal congestion
    10%
  • Nausea
    8%
  • Upper respiratory tract infection
    8%
  • Weight gain
    8%
  • Tremor
    8%
  • Dizziness
    8%
  • Movement disorder
    8%
  • Rash
    8%
  • Increased saliva
    7%
  • Thirst
    7%
See more detailed side effects
13possible side effects
  • Agitation
    9%
  • Weight gain
    7%
  • Headache
    7%
  • Sleepiness
    5%
  • Common cold
    4%
  • Tremors
    4%
  • Fatigue
    3%
  • Increased appetite
    3%
  • Dizziness
    3%
  • Anxiety
    3%
  • Restlessness
    3%
  • Constipation
    2%
  • Decreased cortisol
    2%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • Elderly patients with dementia
  • Neuroleptic malignant syndrome
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Shaking and restlessness
    • High doses of Risperdal (risperidone)
  • Higher blood sugar and cholesterol and weight gain
    • People with diabetes
    • People with high cholesterol
  • Driving impairment
    • Alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings
  • Increased risk of death
    • Elderly patients with dementia
  • Suicidal thoughts or behavior
    • Under 24 years of age
  • Neuroleptic malignant syndrome
  • Difficulty controlling movements
    • Women over age 65
  • Higher blood sugar and cholesterol, and weight gain
    • People with diabetes
    • People with high cholesterol
  • Risk of infection
See more detailed risks and warnings