Compare Robaxin vs. Norflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Robaxin (methocarbamol)

Prescription only

Norflex (orphenadrine)

Prescription only
Relaxes your muscles.

Robaxin (methocarbamol) effectively relieves muscle spasms, but it can cause drowsiness and interfere with your ability to drive.

Relaxes your muscles.

Norflex (orphenadrine) can be used for relaxing muscle spasms and it also can relieve pain.

  • Effective for relieving muscle spasms and pain.
  • For those with trouble swallowing, the pills can be crushed and mixed with food or liquid.
  • Available in generic form and cheaper than other muscle relaxants.
  • Might be a better treatment option for those with a history of drug abuse since Robaxin (methocarbamol) has a low potential for causing addiction and dependence.
  • More effective than placebo for treatment of muscle spasms and nonspecific musculoskeletal pain in the short term.
  • Extended release pills last 12 hours.
  • Available as generic.
  • Robaxin (methocarbamol) can make you sleepy so you might not be able to drive or do certain activities requiring concentration.
  • Need to take a few times throughout the day to maintain effect.
  • Might not be safe to use in people age 65 or older due to increased sensitivity to side effects such as drowsiness.
  • Researches do not know the safety and effectiveness of Robaxin (methocarbamol) in people under age 16.
  • Can be dangerous when used together with other medicines that also cause drowsiness such as narcotics.
  • Not a first choice treatment for muscle spasms.
  • Norflex (orphenadrine) can make you sleepy or drowsy.
  • At higher doses, Norflex (orphenadrine) can make you confused or hallucinate.
  • Dry mouth and difficulty urinating can happen at higher doses.
  • Pills cannot be crushed and must be swallowed whole.
  • Can't be used in people with glaucoma, certain types of bowel obstruction or peptic ulcers, prostatic hypertrophy, certain urinary problems, cardio-spasm (megaesophagus) and myasthenia gravis.
Used for
Dosage forms
  • Pill
  • Extended release pill
  • Pill
  • Injection
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Side effects
The Robaxin (methocarbamol) FDA package insert doesn’t have numbers about how common side effects are.
The Norflex (orphenadrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Drowsiness
    • Taking other medicines that also cause drowsiness
    • Drinking alcohol
    • People age 65 or older
  • Harm to fetus (unborn baby)
    • Women who want to or can become pregnant
    • Pregnant women
See more detailed risks and warnings
  • Sleepiness and dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
  • Abuse, dependence and withdrawal
    • Prior history of drug abuse
  • Heart problems
    • History of fast or irregular heartbeat
    • History of heart failure or other heart problems
See more detailed risks and warnings