Compare Robaxin vs. Skelaxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relaxes your muscles.

Robaxin (methocarbamol) effectively relieves muscle spasms, but it can cause drowsiness and interfere with your ability to drive.

Relaxes your muscles.

Skelaxin (metaxalone) is used for muscle spasms and musculoskeletal pain with mixed results.

Upsides
  • Effective for relieving muscle spasms and pain.
  • For those with trouble swallowing, the pills can be crushed and mixed with food or liquid.
  • Available in generic form and cheaper than other muscle relaxants.
  • Might be a better treatment option for those with a history of drug abuse since Robaxin (methocarbamol) has a low potential for causing addiction and dependence.
  • Can be used for muscle spasms and muscle pain if other medications have not worked.
  • Available as generic.
  • Slightly less sedation and side effects compared to other muscle relaxants.
Downsides
  • Robaxin (methocarbamol) can make you sleepy so you might not be able to drive or do certain activities requiring concentration.
  • Need to take a few times throughout the day to maintain effect.
  • Might not be safe to use in people age 65 or older due to increased sensitivity to side effects such as drowsiness.
  • Researches do not know the safety and effectiveness of Robaxin (methocarbamol) in people under age 16.
  • Can be dangerous when used together with other medicines that also cause drowsiness such as narcotics.
  • Effects don't last that long. You need to take Skelaxin (metaxalone) up to 3-4 times daily.
  • Several studies showed mixed results when Skelaxin (metaxalone) was compared with a sugar pill for treatment of muscle spasms and musculoskeletal pain.
  • Can make you very drowsy or sleepy
  • Even though a generic is available, it is still fairly expensive.
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Used for
  • Musculoskeletal pain
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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Side effects
The Robaxin (methocarbamol) FDA package insert doesn’t have numbers about how common side effects are.
The Skelaxin (metaxalone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Drowsiness
    • Taking other medicines that also cause drowsiness
    • Drinking alcohol
    • People age 65 or older
  • Harm to fetus (unborn baby)
    • Women who want to or can become pregnant
    • Pregnant women
See more detailed risks and warnings
  • Sleepiness and dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
  • Serotonin syndrome
    • Taking antidepressants
    • Higher than recommended doses of Skelaxin (metaxalone)
  • Liver damage
    • History of liver disease
  • Liver or Kidney problems
    • History of liver disease
    • History of kidney disease
See more detailed risks and warnings