Compare Robaxin vs. Zanaflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Robaxin (methocarbamol)

Prescription only

Zanaflex (tizanidine)

Prescription only
Relaxes your muscles.

Robaxin (methocarbamol) effectively relieves muscle spasms, but it can cause drowsiness and interfere with your ability to drive.

Relaxes your muscles.

Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity. Try other options before using this.

4.3/ 5 average rating with 26 reviewsforZanaflex
  • Effective for relieving muscle spasms and pain.
  • For those with trouble swallowing, the pills can be crushed and mixed with food or liquid.
  • Available in generic form and cheaper than other muscle relaxants.
  • Might be a better treatment option for those with a history of drug abuse since Robaxin (methocarbamol) has a low potential for causing addiction and dependence.
  • Relieves muscle spasticity.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
  • Robaxin (methocarbamol) can make you sleepy so you might not be able to drive or do certain activities requiring concentration.
  • Need to take a few times throughout the day to maintain effect.
  • Might not be safe to use in people age 65 or older due to increased sensitivity to side effects such as drowsiness.
  • Researches do not know the safety and effectiveness of Robaxin (methocarbamol) in people under age 16.
  • Can be dangerous when used together with other medicines that also cause drowsiness such as narcotics.
  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Takes over an hour to kick in and only lasts 3 to 6 hours.
  • Zanaflex (tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (tizanidine).
Used for
Dosage forms
  • Pill
  • Pill
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26 reviews so far
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Side effects
The Robaxin (methocarbamol) FDA package insert doesn’t have numbers about how common side effects are.
17possible side effects
  • Dry mouth
  • Sleepiness
  • Weakness
  • Dizziness
  • Urinary tract infection
  • General infection
  • Liver test abnormality
  • Constipation
  • Vomiting
  • Speech disorder
  • Blurred vision
  • Urinary frequency
  • Flu syndrome
  • Involuntary muscle movement
  • Nervousness
  • Sore throat
  • Hay fever
See more detailed side effects
Risks and risk factors
  • Drowsiness
    • Taking other medicines that also cause drowsiness
    • Drinking alcohol
    • People age 65 or older
  • Harm to fetus (unborn baby)
    • Women who want to or can become pregnant
    • Pregnant women
See more detailed risks and warnings
  • Liver damage
    • Taking maximum doses of Zanaflex (tizanidine)
  • Dizziness and low blood pressure
    • Age 65 years or older
    • Currently on blood pressure control medications
  • Sleepiness and driving impairment
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
    • Elderly
  • Withdrawal side effects
    • Stopping Zanaflex (tizanidine) suddenly
See more detailed risks and warnings