Compare Robitussin DM vs. Nyquil Cold And Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Breaks up mucus and relieves cough.

Robitussin Dm (Guaifenesin / Dextromethorphan) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up. You have to take it more often than other guaifenesin products.

3.7/ 5 average rating with 724 reviewsforRobitussin DM
Relieves cold and flu symptoms, and helps you sleep.

Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.

3.8/ 5 average rating with 1188 reviewsforNyquil Cold And Flu
Upsides
  • Robitussin Dm (Guaifenesin / Dextromethorphan) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have chest congestion and a cough.
  • Helps loosen the mucus and phlegm that builds up and causes productive, wet coughs.
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
Downsides
  • Robitussin Dm (Guaifenesin / Dextromethorphan) isn’t useful if you have a dry cough without mucus or phlegm.
  • The two medications in this product could potentially work against each other. Guaifenesin makes mucus easier to cough up, while dextromethorphan (the "DM" in Robitussin Dm (Guaifenesin / Dextromethorphan)) stops you from coughing.
  • Needs to be taken more often during the day than other products with guaifenesin, like Mucinex.
  • Can cause sleepiness, dizziness, and an upset stomach.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
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Used for
Dosage forms
  • Liquid
  • Pill
  • Liquid
No pricing information available
No pricing information available
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Reviews
724 reviews so far
75%
saidit'sworth it
37%
saiditworked well
7%
saidit'sa big hassle

Have you used Robitussin Dm (Guaifenesin / Dextromethorphan)?

Leave a review
1188 reviews so far
83%
saidit'sworth it
42%
saiditworked well
7%
saidit'sa big hassle

Have you used Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)?

Leave a review
Side effects
The Robitussin Dm (Guaifenesin / Dextromethorphan) FDA package insert doesn’t have numbers about how common side effects are.
The Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Nausea and vomiting
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Cough warning
See more detailed risks and warnings
  • Liver damage
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Driving impairment
    • Taking with alcohol
    • Taking with other medicines that make you less alert
  • Antihistamine side effects
    • Age 65 years or older
    • Glaucoma
    • Benign prostatic hypertrophy (BPH)
See more detailed risks and warnings