Compare Rozerem vs. Silenor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Helps you fall asleep.

Rozerem (ramelteon) is a good sleep medicine that's not addictive, but it can be expensive.

Helps you relax, and sleep.

Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.

Upsides
  • Rozerem (ramelteon) isn't a controlled medicine, and it's safe to use in people age 65 or older.
  • If you stop taking Rozerem (ramelteon) suddenly, your insomnia won't come back.
  • Rozerem (ramelteon) won't make you feel hungover or groggy the next day.
  • In a clinical trial Doxepin was able to significantly improve sleep quality.
  • Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
  • Once your body gets used to Doxepin, most of the side effects go away.
  • Doxepin comes in a generic form, so it is pretty cheap.
  • Doxepin is not addictive.
Downsides
  • Rozerem (ramelteon) is only available as a brand name.
  • Rozerem (ramelteon) is only available in 1 strength.
  • If you take Rozerem (ramelteon) on a full stomach, it won't work as well.
  • Not recommended for children.
  • Rozerem (ramelteon) can't be used if you have sleep apnea.
  • Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
  • Doxepin can increase your appetite, leading to weight gain.
  • Taking Doxepin can make emptying your bladder difficult.
  • Some people have suicidal thoughts when taking Doxepin.
  • Doxepin can interact with many different medications, vitamins, and alternative treatments.
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Used for
  • Alcoholism - Anxiety - Depression Anxiety - Depression Anxiety - Depression - Psychoneurotic personality disorder Insomnia Pruritus (Moderate)
  • Due to atopic dermatitis or lichen simplex chronicus
  • Urticaria
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
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Side effects
5possible side effects
  • Dizziness
    4%
  • Sleepiness
    3%
  • Fatigue
    3%
  • Nausea
    3%
  • Worsening insomnia
    3%
See more detailed side effects
The Silenor (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Severe allergic reaction
  • Behavior changes
  • Sleepiness
  • Breathing problems
    • Alcohol
    • Taking narcotics, tranquilizers, or antihistamines
  • Hormonal changes
See more detailed risks and warnings
No information currently available