Compare Sancuso vs. Reglan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Sancuso (granisetron)

Prescription only

Reglan (metoclopramide)

Prescription only
Helps reduce nausea and vomiting.

Sancuso (granisetron) is a good choice to reduce nausea and vomiting if it's hard for you to take oral medicines, but is very expensive.

Relieves nausea and vomiting.

Reglan (metoclopramide) can stimulate your gut and relieve nausea, but it can only be used for a short period of time due to avoid serious side-effects.

Upsides
  • Each Sancuso (granisetron) patch provides around-the-clock relief from nausea and vomiting for up to 7 days without having to re-dose and without problems associated with missing a dose.
  • May be a better option for some people on multi-day chemotherapy regimens.
  • Especially useful for relieving nausea caused by cancer chemotherapy.
  • Available in an affordable, generic version
  • If tablets are hard for you to swallow, Reglan (metoclopramide) is also available in as an orally disintegrating tablet or liquid form.
Downsides
  • Must be applied at least 24 hours before the scheduled chemotherapy.
  • Sancuso (granisetron) has the possibility of interacting with antidepressants that can result in a dangerous build up of serotonin.
  • Must restrict from certain activites such as swimming and strenous excerise while wearing Sancuso (granisetron).
  • Should be used with caution in people with any heart condition.
  • Use for more than 12 weeks can cause involuntary movements of the eyes, tongue, face, arm, or legs.
  • May take a while to relieve nausea and vomiting caused by delayed gastric emptying.
  • Not a good option if you have Parkinson's disease, history of seizures, or blockage in your gut.
  • You may need a lower dose if you have kidney problems.
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Used for
  • Diabetic gastroparesis
  • Gastroesophegeal reflux
  • Prevention of nausea and vomiting associated with chemotherapy
  • Prevention of postoperative nausea and vomiting
  • Radiological exam
  • Small bowel intubation
  • Gastric bezoars
  • Hiccups
  • Acute migraine
  • Treatment of nausea and vomiting in advanced cancer
  • Prevention of radiation therapy-induced nausea and vomiting
Dosage forms
  • Patch
  • Pill
  • Dissolving tablet
  • Liquid
  • Injectable
Price
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Reviews
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Side effects
The Sancuso (granisetron) FDA package insert doesn’t have numbers about how common side effects are.
4possible side effects
  • Restlessness
    10%
  • Drowsiness
    10%
  • Fatigue
    10%
  • Lack of energy
    10%
See more detailed side effects
Risks and risk factors
  • Rare serious drug interaction
    • Taking other medicines that affect serotonin levels such as tramadol and anti-depressants
  • Heart disease
  • Masking of intestinal blockage and stomach bloating
  • Skin reactions
  • Heat exposure
    • Exposure to heat
  • Sun exposure
    • Exposure to sun
See more detailed risks and warnings
  • Late, irreversible, involuntary movements (tardive dyskinesia)
    • Elderly
    • Women
    • Diabetics
  • Depression
    • Depression
  • Neuroleptic malignant syndrome
  • Early, reversible involuntary movements (extrapyramidal side-effects)
    • Younger than 30 years old
    • High doses of Reglan (metoclopramide)
    • Children and teens
See more detailed risks and warnings