Compare Sancuso vs. Sustol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Helps reduce nausea and vomiting.

Sancuso (granisetron) is a good choice to reduce nausea and vomiting if it's hard for you to take oral medicines, but is very expensive.

Helps prevent nausea and vomiting due to cancer chemotherapies.

Sustol (granisetron) is a long-acting injection that helps to prevent nausea and vomiting due to cancer chemotherapies, but causes bleeding and bruising at the injection site.

Upsides
  • Each Sancuso (granisetron) patch provides around-the-clock relief from nausea and vomiting for up to 7 days without having to re-dose and without problems associated with missing a dose.
  • May be a better option for some people on multi-day chemotherapy regimens.
  • Each dose of Sustol (granisetron) provides relief from nausea and vomiting for at least 7 days.
  • Dosing is less frequent than alternatives.
  • Injection may be preferrable if you have difficulty swallowing a pill.
Downsides
  • Must be applied at least 24 hours before the scheduled chemotherapy.
  • Sancuso (granisetron) has the possibility of interacting with antidepressants that can result in a dangerous build up of serotonin.
  • Must restrict from certain activites such as swimming and strenous excerise while wearing Sancuso (granisetron).
  • Should be used with caution in people with any heart condition.
  • Sustol (granisetron) must be given at the doctor's office or infusion center 30 minutes before chemotherapy.
  • The dose of Sustol (granisetron) needs to be adjusted if you have poor kidney function.
  • Available as an expensive, branded product only.
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Used for
  • Prevention of nausea and vomiting due to cancer chemotherapy
Dosage forms
  • Patch
  • Extended-release injection
Price
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Reviews
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Side effects
The Sancuso (granisetron) FDA package insert doesn’t have numbers about how common side effects are.
The Sustol (granisetron) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Rare serious drug interaction
    • Taking other medicines that affect serotonin levels such as tramadol and anti-depressants
  • Heart disease
  • Masking of intestinal blockage and stomach bloating
  • Skin reactions
  • Heat exposure
    • Exposure to heat
  • Sun exposure
    • Exposure to sun
See more detailed risks and warnings
  • Serotonin syndrome
    • Taking other medicines that affect serotonin levels such as anti-depressants
  • Troublesome stomach side-effects (ileus)
    • Taking other medications that cause constipation such as Norco and Percocet.
  • Injection site reactions
    • Bruising/bleeding more likely if also taking medications that affect blood coagulation
  • Allergic reactions
See more detailed risks and warnings