Compare Sandimmune vs. Afinitor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Sandimmune (cyclosporine)

Prescription only

Afinitor (everolimus)

Prescription only
Suppresses the immune system.

Sandimmune (cyclosporine) is good at preventing rejection of an organ transplant, but it's more difficult to monitor than Neoral/Gengraf (cyclosporine modified) and isn't good for people with kidney problems.

Treats different types of cancer.

Treats different types of cancer, but can cause uncomfortable side effects.

Upsides
  • Sandimmune (cyclosporine) is good at preventing organ rejection.
  • Can take Sandimmune (cyclosporine) if you’re pregnant.
  • Less effect on blood sugar than other medicines in its class like tacrolimus.
  • Conveniently taken once daily.
  • Afinitor (everolimus) comes as a pill rather than an injection, unlike some other cancer drugs.
Downsides
  • You’ll need regular blood tests, especially in the beginning, to make sure Sandimmune (cyclosporine) isn't affecting your body in a bad way.
  • Can cause high blood pressure and kidney damage, especially with lifelong use.
  • You might need to take other medicines to control your blood pressure while on Sandimmune (cyclosporine).
  • Afinitor (everolimus) has many uncomfortable and potentially intolerable side effects.
  • You may be more prone to infections and take longer to recover from a wound while taking Afinitor (everolimus).
  • Some prescription medications, vitamins and supplements can interfere with how Afinitor (everolimus) works.
  • Afinitor (everolimus) might not be the best option if you have liver problems.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price
$14450.00
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Reviews
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Side effects
17possible side effects
  • High blood pressure
    53%
  • Abnormal kidney function
    38%
  • Tremor
    31%
  • Abnormal hair growth
    28%
  • Headache
    15%
  • Nausea/vomiting
    10%
  • Liver damage
    7%
  • Stomach discomfort
    7%
  • Low white blood cells
    6%
  • Blood cell tumor
    6%
  • Gum swelling
    5%
  • Uncontrolled shaking
    4%
  • Diarrhea
    4%
  • Swelling of breasts
    4%
  • Common cold symptoms
    3%
  • Acne
    2%
  • Burning or tingling in hands, arms, legs, or feet
    2%
See more detailed side effects
34possible side effects
  • Mouth sores
    70%
  • Rash
    59%
  • Diarrhea
    50%
  • Tiredness
    45%
  • Swelling
    39%
  • Stomach pain
    36%
  • Nausea
    32%
  • Fever
    31%
  • Decreased appetite
    30%
  • Headache
    30%
  • Vomiting
    28%
  • Weight loss
    28%
  • Common cold
    25%
  • Cough
    25%
  • Nosebleed
    22%
  • Nail disorder
    22%
  • Itchy skin
    21%
  • Difficulty breathing
    20%
  • Weakness
    19%
  • Decreased taste sensitivity
    19%
  • Lung inflammation
    17%
  • Urinary tract infection
    16%
  • Joint pain
    15%
  • Back pain
    15%
  • Constipation
    14%
  • Pain in extremity
    14%
  • Difficulty sleeping
    14%
  • Dry skin
    13%
  • High blood pressure
    13%
  • Dizziness
    12%
  • Dry mouth
    11%
  • Throat pain
    11%
  • Diabetes
    10%
  • Muscle spasms
    10%
See more detailed side effects
Risks and risk factors
  • Cancer
    • Taking Sandimmune (cyclosporine) for a long time
    • Prolonged exposure to sunlight
    • UV light
  • Hard-to-predict absorption
  • Kidney damage
    • Taking Sandimmune (cyclosporine) for a long time
    • Taking high doses of Sandimmune (cyclosporine)
    • Poor kidney function
    • Donor age 50 or older
    • Taking other medicines that can damage the kidneys
    • Taking medicines that interact with Sandimmune (cyclosporine)
  • Serious infections
    • Taking other immunosuppressants
    • Age 60 or older
    • Weak immune system
  • High blood pressure
    • High blood pressure
    • Taking other medicines that can raise blood pressure
  • Drug interactions
    • Taking multiple medicines
See more detailed risks and warnings
  • Infection
  • Kidney disease
  • Lung problems
  • Reaction to live vaccines
  • Swelling of the airways or tongue
    • Taking ACE inhibitor
  • Mouth ulcers
See more detailed risks and warnings