Compare Seroquel vs. fluphenazine decanoate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Helps control your thoughts and mood.

Seroquel (quetiapine) is a effective at treating schizophrenia, mania, and depression but it can cause weight gain and high blood glucose levels.

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3.7/ 5 average rating with 250 reviewsforSeroquel
Treats schizophrenia or psychosis.

Prolixin Decanoate (fluphenazine decanoate) is long-acting medicine for stabilizing your mood that must be given by a trained healthcare professional.

Upsides
  • Seroquel (quetiapine) is effective at relieving psychotic symptoms and manic episodes.
  • Seroquel (quetiapine) has fewer side effects than most antipsychotic medications.
  • Seroquel (quetiapine) is less likely to cause heart problems compared to some other antipsychotics.
  • Seroquel (quetiapine) is also the least likely to cause Extrapyramidal Symptoms (EPS) – a movement disorder that causes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Can be given less frequently than the oral, short-acting version.
  • Available in generic.
Downsides
  • Seroquel (quetiapine) has a moderate to high risk of weight gain, elevated cholesterol and/or blood sugar compared to other antipsychotics.
  • You might need routine blood tests to check how Seroquel (quetiapine) is affecting your body.
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can only be used if you're already stable on the short-acting version of this medicine.
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Used for
Dosage forms
  • Pill
  • Extended release
  • Injection
Price
Lowest price
$19.95
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Reviews
250 reviews so far
56%
saidit'sworth it
50%
saiditworked well
27%
saidit'sa big hassle

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Side effects
36possible side effects
  • Drowsiness
    34%
  • Dry mouth
    19%
  • Headache
    17%
  • Weakness
    10%
  • Constipation
    10%
  • Dizziness
    9%
  • Tremor
    8%
  • Stomach pain
    7%
  • Low blood pressure
    7%
  • Agitation
    6%
  • Weight gain
    6%
  • Sore throat
    6%
  • Back pain
    5%
  • Stiffness/difficulty moving
    4%
  • Hay fever
    4%
  • Swelling in the limbs
    4%
  • Twitching
    4%
  • Indigestion
    4%
  • Depression
    3%
  • Lazy eye
    3%
  • Speech disorder
    3%
  • Altered hormone levels
    3%
  • Heaviness
    2%
  • Infection
    2%
  • Fever
    2%
  • High blood pressure
    2%
  • Increased heart rate
    2%
  • Increased appetite
    2%
  • Hypothyroidism
    2%
  • Incoordination
    2%
  • Abnormal thinking
    2%
  • Anxiety
    2%
  • Loss of control of movements
    2%
  • Sinus infection
    2%
  • Sweating
    2%
  • Urinary Tract Infection
    2%
See more detailed side effects
The Prolixin Decanoate (fluphenazine decanoate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of death
    • Elderly patients with dementia-related psychosis
  • Suicidal thoughts or behavior
    • Children, adolescents, and young adults (<24 years old)
  • Neuroleptic malignant syndrome
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Extrapyramidal Symptoms (EPS)
  • Metabolic changes (increased blood sugar, high cholesterol and weight gain)
    • People with diabetes
    • People with high cholesterol
See more detailed risks and warnings
  • Increased risk of death
    • People over 65 with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Low white blood cell count
See more detailed risks and warnings
Learn more about Seroquel (quetiapine)
Learn more about Prolixin Decanoate (fluphenazine decanoate)