Compare Seroquel vs. Rexulti

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Seroquel (quetiapine)

Prescription only

Rexulti (brexpiprazole)

Prescription only
Helps control your thoughts and mood.

Seroquel (quetiapine) is a effective at treating schizophrenia, mania, and depression but it can cause weight gain and high blood glucose levels.

3.7/ 5 average rating with 250 reviewsforSeroquel
Helps improve your mood and control your thoughts.

Rexulti (brexpiprazole) is an option for people with depression or schizophrenia but it can be more expensive than other medicines.

Upsides
  • Seroquel (quetiapine) is effective at relieving psychotic symptoms and manic episodes.
  • Seroquel (quetiapine) has fewer side effects than most antipsychotic medications.
  • Seroquel (quetiapine) is less likely to cause heart problems compared to some other antipsychotics.
  • Seroquel (quetiapine) is also the least likely to cause Extrapyramidal Symptoms (EPS) – a movement disorder that causes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Rexulti (brexpiprazole) does not cause as much weight gain as other similar medications.
  • Fewer side effects compared to other similar medications.
Downsides
  • Seroquel (quetiapine) has a moderate to high risk of weight gain, elevated cholesterol and/or blood sugar compared to other antipsychotics.
  • You might need routine blood tests to check how Seroquel (quetiapine) is affecting your body.
  • Avaliable only as brand name and can be more expensive than other options. However, there may be programs to help with co-pays.
  • Rexulti (brexpiprazole) can cause restlessness, especially when you take higher doses and after a long period of time.
  • Can increase your cholesterol, blood sugar, and cause weight gain.
  • Elderly patients with dementia should not take Rexulti (brexpiprazole).
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Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
Price
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Reviews
250 reviews so far
56%
saidit'sworth it
50%
saiditworked well
27%
saidit'sa big hassle

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Side effects
36possible side effects
  • Drowsiness
    34%
  • Dry mouth
    19%
  • Headache
    17%
  • Weakness
    10%
  • Constipation
    10%
  • Dizziness
    9%
  • Tremor
    8%
  • Stomach pain
    7%
  • Low blood pressure
    7%
  • Agitation
    6%
  • Weight gain
    6%
  • Sore throat
    6%
  • Back pain
    5%
  • Stiffness/difficulty moving
    4%
  • Hay fever
    4%
  • Swelling in the limbs
    4%
  • Twitching
    4%
  • Indigestion
    4%
  • Depression
    3%
  • Lazy eye
    3%
  • Speech disorder
    3%
  • Altered hormone levels
    3%
  • Heaviness
    2%
  • Infection
    2%
  • Fever
    2%
  • High blood pressure
    2%
  • Increased heart rate
    2%
  • Increased appetite
    2%
  • Hypothyroidism
    2%
  • Incoordination
    2%
  • Abnormal thinking
    2%
  • Anxiety
    2%
  • Loss of control of movements
    2%
  • Sinus infection
    2%
  • Sweating
    2%
  • Urinary Tract Infection
    2%
See more detailed side effects
13possible side effects
  • Agitation
    9%
  • Weight gain
    7%
  • Headache
    7%
  • Sleepiness
    5%
  • Common cold
    4%
  • Tremors
    4%
  • Fatigue
    3%
  • Increased appetite
    3%
  • Dizziness
    3%
  • Anxiety
    3%
  • Restlessness
    3%
  • Constipation
    2%
  • Decreased cortisol
    2%
See more detailed side effects
Risks and risk factors
  • Higher risk of death
    • Elderly patients with dementia-related psychosis
  • Suicidal thoughts or behavior
    • Children, adolescents, and young adults (<24 years old)
  • Neuroleptic malignant syndrome
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Extrapyramidal Symptoms (EPS)
  • Metabolic changes (increased blood sugar, high cholesterol and weight gain)
    • People with diabetes
    • People with high cholesterol
See more detailed risks and warnings
  • Increased risk of death
    • Elderly patients with dementia
  • Suicidal thoughts or behavior
    • Under 24 years of age
  • Neuroleptic malignant syndrome
  • Difficulty controlling movements
    • Women over age 65
  • Higher blood sugar and cholesterol, and weight gain
    • People with diabetes
    • People with high cholesterol
  • Risk of infection
See more detailed risks and warnings