Compare Seroquel vs. Rexulti
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Helps control your thoughts and mood.
Seroquel (quetiapine) is a effective at treating schizophrenia, mania, and depression but it can cause weight gain and high blood glucose levels.
●●●●●
3.7/ 5 average rating with 250 reviewsforSeroquel
Helps improve your mood and control your thoughts.
Rexulti (brexpiprazole) is an option for people with depression or schizophrenia but it can be more expensive than other medicines.
Upsides
- Seroquel (quetiapine) is effective at relieving psychotic symptoms and manic episodes.
- Seroquel (quetiapine) has fewer side effects than most antipsychotic medications.
- Seroquel (quetiapine) is less likely to cause heart problems compared to some other antipsychotics.
- Seroquel (quetiapine) is also the least likely to cause Extrapyramidal Symptoms (EPS) – a movement disorder that causes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
- Rexulti (brexpiprazole) does not cause as much weight gain as other similar medications.
- Fewer side effects compared to other similar medications.
Downsides
- Seroquel (quetiapine) has a moderate to high risk of weight gain, elevated cholesterol and/or blood sugar compared to other antipsychotics.
- You might need routine blood tests to check how Seroquel (quetiapine) is affecting your body.
- Avaliable only as brand name and can be more expensive than other options. However, there may be programs to help with co-pays.
- Rexulti (brexpiprazole) can cause restlessness, especially when you take higher doses and after a long period of time.
- Can increase your cholesterol, blood sugar, and cause weight gain.
- Elderly patients with dementia should not take Rexulti (brexpiprazole).
Used for
Dosage forms
- Pill
- Extended release
- Pill
Price
Lowest price
$13.87
Find instant savings near youLowest price
$1219.63
Find instant savings near youWant to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
250 reviews so far
56%
saidit'sworth it
50%
saiditworked well
27%
saidit'sa big hassle
Have you used Seroquel (quetiapine)?
Leave a reviewNot enough review data.Leave a review
Side effects
36possible side effects
- Drowsiness34%
- Dry mouth19%
- Headache17%
- Weakness10%
- Constipation10%
- Dizziness9%
- Tremor8%
- Stomach pain7%
- Low blood pressure7%
- Agitation6%
- Weight gain6%
- Sore throat6%
- Back pain5%
- Stiffness/difficulty moving4%
- Hay fever4%
- Swelling in the limbs4%
- Twitching4%
- Indigestion4%
- Depression3%
- Lazy eye3%
- Speech disorder3%
- Altered hormone levels3%
- Heaviness2%
- Infection2%
- Fever2%
- High blood pressure2%
- Increased heart rate2%
- Increased appetite2%
- Hypothyroidism2%
- Incoordination2%
- Abnormal thinking2%
- Anxiety2%
- Loss of control of movements2%
- Sinus infection2%
- Sweating2%
- Urinary Tract Infection2%
13possible side effects
- Agitation9%
- Weight gain7%
- Headache7%
- Sleepiness5%
- Common cold4%
- Tremors4%
- Fatigue3%
- Increased appetite3%
- Dizziness3%
- Anxiety3%
- Restlessness3%
- Constipation2%
- Decreased cortisol2%
Risks and risk factors
- Higher risk of death
- Elderly patients with dementia-related psychosis
- Suicidal thoughts or behavior
- Children, adolescents, and young adults (<24 years old)
- Neuroleptic malignant syndrome
- Heart problems
- History of heart problems
- Drug interactions
- Extrapyramidal Symptoms (EPS)
- Metabolic changes (increased blood sugar, high cholesterol and weight gain)
- People with diabetes
- People with high cholesterol
- Increased risk of death
- Elderly patients with dementia
- Suicidal thoughts or behavior
- Under 24 years of age
- Neuroleptic malignant syndrome
- Difficulty controlling movements
- Women over age 65
- Higher blood sugar and cholesterol, and weight gain
- People with diabetes
- People with high cholesterol
- Risk of infection