Compare Silenor vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Helps you relax, and sleep.

Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.

Improves mood.

Pamelor (nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain, but may take 6 to 8 weeks to feel the full effects on your mood.

4.0/ 5 average rating with 19 reviewsforPamelor
Upsides
  • In a clinical trial Doxepin was able to significantly improve sleep quality.
  • Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
  • Once your body gets used to Doxepin, most of the side effects go away.
  • Doxepin comes in a generic form, so it is pretty cheap.
  • Doxepin is not addictive.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Available as a generic in 2 different forms: capsule and liquid.
Downsides
  • Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
  • Doxepin can increase your appetite, leading to weight gain.
  • Taking Doxepin can make emptying your bladder difficult.
  • Some people have suicidal thoughts when taking Doxepin.
  • Doxepin can interact with many different medications, vitamins, and alternative treatments.
  • Side effects are usually manageable, but can be annoying.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
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Used for
  • Alcoholism - Anxiety - Depression Anxiety - Depression Anxiety - Depression - Psychoneurotic personality disorder Insomnia Pruritus (Moderate)
  • Due to atopic dermatitis or lichen simplex chronicus
  • Urticaria
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
Not enough review data.Leave a review
19 reviews so far
79%
saidit'sworth it
79%
saiditworked well
21%
saidit'sa big hassle

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Side effects
The Silenor (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
The Pamelor (nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
No information currently available
  • Suicidal thoughts or behavior
    • Age 24 years or younger
    • Changing the dose
  • Dizziness and falls
    • Age 65 years or older
    • Other blood pressure lowering medications
  • Eye problems
    • Glaucoma
  • Rare, life-threatening
    • Antidepressants
    • Lithium
    • Triptans
    • St. John's wort
    • Fentanyl
    • Tramadol
    • MAO inhibitors
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings