Compare Simbrinza vs. pilocarpine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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lowers eye pressure

Simbrinza ia an effective two medicine combination that is used when one medication alone is not effective, and you are looking for ease of using both medications in one drop.

Lowers eye pressure and constricts the pupil.

Isopto Carpine (pilocarpine) is a very effective first choice medicine for treating high eye pressure to prevent the onset or worsening of glaucoma, but you may have to use up to 4 times daily.

Upsides
  • Simbrinza may be more effective because it contains two medications
  • It is easier to take two medications in one drop.
  • It takes about 1 hour for Isopto Carpine (pilocarpine) to lower dangerously high eye pressure.
  • It does not require dose adjustments in patients with liver or kidney problems.
  • Available as a generic.
Downsides
  • Simbrinza may cause carbonated beverages to taste metallic..
  • You must wait 5 minutes before using another eye drop
  • Remove contact lenses and leave out for 15 minutes after using the the eyedrop
  • Not used in children under 2 years of age
  • Isopto Carpine (pilocarpine) causes the pupil of the eye to become smaller, which results in dim vision, particularly at night.
  • Alternatives are easier to use than this medication, since it requires more drops throughout the day.
  • Isopto Carpine (pilocarpine) is a recommended choice, but it may not work for more serious conditions.
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Used for
  • Ocular hypertension Open-angle glaucoma
Dosage forms
  • Eye drops
  • Eye drops
Price
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Reviews
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Side effects
The Simbrinza (Brinzolamide / Brimonidine) FDA package insert doesn’t have numbers about how common side effects are.
The Isopto Carpine (pilocarpine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
No information currently available
  • Reduced visual acuity
  • Retinal disease
    • Retinal disease
  • Increased intraocular pressure in children
    • Use of Isopto Carpine (pilocarpine) in pediatric patients
See more detailed risks and warnings