Compare Sirturo vs. Avelox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Sirturo (bedaquiline)

Prescription only

Avelox (moxifloxacin)

Prescription only
Used to treat active tuberculosis when other medications cannot be used.

Sirturo (bedaquiline) is a great addition to tuberculosis regimens but only if your tuberculosis can't be treated with all of the typical tuberculosis drugs.

Treats bacterial infections.

Avelox (moxifloxacin) effectively treats different types of bacterial infections, but is more expensive than its alternatives.

Upsides
  • Sirturo (bedaquiline) is the first drug with a new method of treating multi-drug resistant tuberculosis to be developed in over 40 years.
  • After two weeks of taking Sirturo (bedaquiline) each day, you will only need to take it three times a week for the rest of your therapy.
  • Available as a generic medicine.
  • Treats a variety of bacterial infections.
  • Can be taken with or without food.
  • Might be a good treatment option for people with kidney problems.
  • Needs to be taken only once a day.
Downsides
  • Sirturo (bedaquiline) should not be taken alone to treat your tuberculosis. You must take it with at least 3 other medications.
  • It is recommended you take Sirturo (bedaquiline) by directly observed therapy or in front of a health worker.
  • Like other tuberculosis drugs, Sirturo (bedaquiline) has to be given for several months in order for it work properly (usually 6 months).
  • A study found an increased risk of death with Sirturo (bedaquiline). You can only take it when the standard tuberculosis treament is not enough to treat you of tuberculosis.
  • Sirturo (bedaquiline) cannot be used for latent (or non-active) tuberculosis or for tuberculosis that has spread outside the lungs.
  • People with diabetes need to check their blood sugar levels regularly while taking Avelox (moxifloxacin).
  • Cannot be taken at the same time as antacids or vitamins.
  • Avelox (moxifloxacin) can increase your skin's sensitivity to sunlight and make you more likely to get a rash.
  • Relatively more expensive compared to similar alternatives.
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Used for
  • Pulmonary tuberculosis
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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Side effects
9possible side effects
  • Nausea
    38%
  • Joint pain
    33%
  • Headache
    28%
  • Coughing up blood
    18%
  • Chest pain
    11%
  • Loss of appetite
    9%
  • Abnormal liver labs
    9%
  • Rash
    8%
  • Pancreatitis
    3%
See more detailed side effects
8possible side effects
  • Nausea
    7%
  • Diarrhea
    6%
  • Headache
    4%
  • Dizziness
    3%
  • Vomiting
    2%
  • Constipation
    2%
  • Stomach pain
    2%
  • Insomnia
    2%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
  • Heart rhythm problems
    • Use with other QT prolonging drugs
    • History of heart disease
  • Liver damage
    • History of liver damage
    • Alcohol intake
    • Use with other drugs that are harmful to the liver
See more detailed risks and warnings
  • Tendon rupture and inflammation
    • People over age 60
    • Taking steroid medicine
    • Those with kidney, heart, or lung transplants
  • Myasthenia gravis
    • Those with a history of myasthenia gravis
  • Diarrhea
  • Nerve damage
  • Changes in mood and behavior
  • Effects on heartbeat
    • Those with a history of heart rhythm problems
    • Taking other medicines that also affect your heart rhythm
    • Those with liver problems
See more detailed risks and warnings