Compare Sirturo vs. ethambutol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Sirturo (bedaquiline)

Prescription only

Myambutol (ethambutol)

Prescription only
Used to treat active tuberculosis when other medications cannot be used.

Sirturo (bedaquiline) is a great addition to tuberculosis regimens but only if your tuberculosis can't be treated with all of the typical tuberculosis drugs.

Treats and prevents mycobacterial infections like tuberculosis.

Myambutol (ethambutol) works well to treat or prevent mycobacterial infections, but has to be combined with other medicines and taken for a long period of time.

Upsides
  • Sirturo (bedaquiline) is the first drug with a new method of treating multi-drug resistant tuberculosis to be developed in over 40 years.
  • After two weeks of taking Sirturo (bedaquiline) each day, you will only need to take it three times a week for the rest of your therapy.
  • First-choice treatment for tuberculosis.
  • There are different dosing regimens, which can make taking Myambutol (ethambutol) more convenient for your schedule.
  • Myambutol (ethambutol) can be taken with food and may help with any stomach upset.
Downsides
  • Sirturo (bedaquiline) should not be taken alone to treat your tuberculosis. You must take it with at least 3 other medications.
  • It is recommended you take Sirturo (bedaquiline) by directly observed therapy or in front of a health worker.
  • Like other tuberculosis drugs, Sirturo (bedaquiline) has to be given for several months in order for it work properly (usually 6 months).
  • A study found an increased risk of death with Sirturo (bedaquiline). You can only take it when the standard tuberculosis treament is not enough to treat you of tuberculosis.
  • Sirturo (bedaquiline) cannot be used for latent (or non-active) tuberculosis or for tuberculosis that has spread outside the lungs.
  • Remembering to take Myambutol (ethambutol) daily over a long period of time and with other medicines can be difficult.
  • Not a good choice if you have a history or are experiencing any vision problems.
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Used for
  • Pulmonary tuberculosis
  • Tuberculosis
  • Prevention of Mycobacterium avium complex (MAC) infection in HIV, transplant, or cancer patients
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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Side effects
9possible side effects
  • Nausea
    38%
  • Joint pain
    33%
  • Headache
    28%
  • Coughing up blood
    18%
  • Chest pain
    11%
  • Loss of appetite
    9%
  • Abnormal liver labs
    9%
  • Rash
    8%
  • Pancreatitis
    3%
See more detailed side effects
The Myambutol (ethambutol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased risk of death
  • Heart rhythm problems
    • Use with other QT prolonging drugs
    • History of heart disease
  • Liver damage
    • History of liver damage
    • Alcohol intake
    • Use with other drugs that are harmful to the liver
See more detailed risks and warnings
  • Vision problems
  • Liver problems
See more detailed risks and warnings