Compare Sirturo vs. Mycobutin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Used to treat active tuberculosis when other medications cannot be used.

Sirturo (bedaquiline) is a great addition to tuberculosis regimens but only if your tuberculosis can't be treated with all of the typical tuberculosis drugs.

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Upsides
  • Sirturo (bedaquiline) is the first drug with a new method of treating multi-drug resistant tuberculosis to be developed in over 40 years.
  • After two weeks of taking Sirturo (bedaquiline) each day, you will only need to take it three times a week for the rest of your therapy.
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Downsides
  • Sirturo (bedaquiline) should not be taken alone to treat your tuberculosis. You must take it with at least 3 other medications.
  • It is recommended you take Sirturo (bedaquiline) by directly observed therapy or in front of a health worker.
  • Like other tuberculosis drugs, Sirturo (bedaquiline) has to be given for several months in order for it work properly (usually 6 months).
  • A study found an increased risk of death with Sirturo (bedaquiline). You can only take it when the standard tuberculosis treament is not enough to treat you of tuberculosis.
  • Sirturo (bedaquiline) cannot be used for latent (or non-active) tuberculosis or for tuberculosis that has spread outside the lungs.
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Used for
  • Pulmonary tuberculosis
  • Disseminated infection due to Mycobacterium avium-intracellulare group; Prophylaxis - HIV infection
  • Atypical mycobacterial infection Crohn's disease Disseminated infection due to Mycobacterium avium-intracellulare group - HIV infection Helicobacter pylori gastrointestinal tract infection HIV infection - Tuberculosis Mycobacterium avium complex infection
  • Lung disease Tuberculosis Tuberculosis
  • Extrapulmonary
Dosage forms
  • Pill
  • Pill
Price
Lowest price
$3786.09
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Lowest price
$255.61
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Reviews
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Side effects
9possible side effects
  • Nausea
    38%
  • Joint pain
    33%
  • Headache
    28%
  • Coughing up blood
    18%
  • Chest pain
    11%
  • Loss of appetite
    9%
  • Abnormal liver labs
    9%
  • Rash
    8%
  • Pancreatitis
    3%
See more detailed side effects
The Mycobutin (Rifabutin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased risk of death
  • Heart rhythm problems
    • Use with other QT prolonging drugs
    • History of heart disease
  • Liver damage
    • History of liver damage
    • Alcohol intake
    • Use with other drugs that are harmful to the liver
See more detailed risks and warnings
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Learn more about Sirturo (bedaquiline)
Learn more about Mycobutin (Rifabutin)