Compare Skelaxin vs. Gablofen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relaxes your muscles.

Skelaxin (metaxalone) is used for muscle spasms and musculoskeletal pain with mixed results.

Works well to control muscle spasticity.

Gablofen (baclofen) is effective for long term spastic conditions, such as multiple sclerosis, spinal cord injury, and others. It is administered intrathecally by a pump connecting to your spine.

Upsides
  • Can be used for muscle spasms and muscle pain if other medications have not worked.
  • Available as generic.
  • Slightly less sedation and side effects compared to other muscle relaxants.
  • Gablofen (baclofen) is the agent of choice for treatment of muscle spasticity.
  • Gablofen (baclofen) has fewer side effects than the oral form, since higher levels can be delivered to the spine at lower doses.
Downsides
  • Effects don't last that long. You need to take Skelaxin (metaxalone) up to 3-4 times daily.
  • Several studies showed mixed results when Skelaxin (metaxalone) was compared with a sugar pill for treatment of muscle spasms and musculoskeletal pain.
  • Can make you very drowsy or sleepy
  • Even though a generic is available, it is still fairly expensive.
  • Gablofen (baclofen) can cause sleepiness and drowsiness.
  • Stopping Gablofen (baclofen) right away can be life-threatening, so a doctor would need to help you stop it.
  • Gablofen (baclofen) has to be started in the doctor's office. You or your caregiver need to be trained on how to use the pump.
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Used for
  • Musculoskeletal pain
Dosage forms
  • Pill
  • Injection
Price
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Reviews
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Side effects
The Skelaxin (metaxalone) FDA package insert doesn’t have numbers about how common side effects are.
21possible side effects
  • Loss of muscle tone
    35%
  • Drowsiness
    19%
  • Headache
    11%
  • Convulsion
    10%
  • Urinary Retention
    8%
  • Dizziness
    8%
  • Nausea
    7%
  • Increased muscle tone
    6%
  • Vomiting
    4%
  • Slowed breathing
    4%
  • Pain
    4%
  • Itchiness
    4%
  • Increased salivation
    3%
  • Swelling of limbs
    3%
  • Back pain
    2%
  • Constipaiton
    2%
  • Diarrhea
    2%
  • Weak muscles
    2%
  • Pneumonia
    2%
  • Urination control problems
    2%
  • Inability to urinate
    2%
See more detailed side effects
Risks and risk factors
  • Sleepiness and dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
  • Serotonin syndrome
    • Taking antidepressants
    • Higher than recommended doses of Skelaxin (metaxalone)
  • Liver damage
    • History of liver disease
  • Liver or Kidney problems
    • History of liver disease
    • History of kidney disease
See more detailed risks and warnings
  • Withdrawal symptoms
    • Stopping Gablofen (baclofen) too quickly
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Seizures
    • Higher dose
    • Using other medicines that can cause seizures
    • History of seizures
    • Alcoholism
    • Eating disorders
    • Brain infections
See more detailed risks and warnings