Compare Skelaxin vs. Norgesic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relaxes your muscles.

Skelaxin (metaxalone) is used for muscle spasms and musculoskeletal pain with mixed results.

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  • Can be used for muscle spasms and muscle pain if other medications have not worked.
  • Available as generic.
  • Slightly less sedation and side effects compared to other muscle relaxants.
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  • Effects don't last that long. You need to take Skelaxin (metaxalone) up to 3-4 times daily.
  • Several studies showed mixed results when Skelaxin (metaxalone) was compared with a sugar pill for treatment of muscle spasms and musculoskeletal pain.
  • Can make you very drowsy or sleepy
  • Even though a generic is available, it is still fairly expensive.
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Used for
  • Musculoskeletal pain
No indications data available
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Dosage forms
  • Pill
  • Pill
No pricing information available
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Side effects
The Skelaxin (metaxalone) FDA package insert doesn’t have numbers about how common side effects are.
The Norgesic (Orphenadrine / Aspirin / Caffeine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Sleepiness and dizziness
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    • Excessive alcohol use
  • Serotonin syndrome
    • Taking antidepressants
    • Higher than recommended doses of Skelaxin (metaxalone)
  • Liver damage
    • History of liver disease
  • Liver or Kidney problems
    • History of liver disease
    • History of kidney disease
See more detailed risks and warnings
No information currently available