Compare Sonata vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Sonata (Zaleplon)

Prescription only

Zonalon (Doxepin)

Prescription only
Helps you sleep.

Sonata (Zaleplon) helps you fall asleep, but it's not as good for staying asleep. It also interacts with a lot of diseases and other drugs.

2.9/ 5 average rating with 175 reviewsforSonata
Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Upsides
  • Effective at helping people fall asleep faster.
  • Doesn't last as long in the body as some other sleep medicines, so it's okay to take it in the middle of the night as long as you enough time to sleep. (But be sure to discuss it with your doctor first.)
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
Downsides
  • Not typically used for long-term treatment since it can be habit-forming.
  • Doesn't last as long in the body as other sleep medicines, so it's not as good at helping you stay asleep.
  • Interacts badly with many other medications.
  • Not a good option if you're pregnant or breast-feeding.
  • People have sleep-walked, sleep-driven, and sleep-eaten while on Sonata (Zaleplon).
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
  • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behaviors so you can sleep better naturally.
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
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Used for
  • Skin intching (moderate)
Dosage forms
  • Pill
  • Cream, gel, or ointment
Price
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Reviews
175 reviews so far
42%
saidit'sworth it
23%
saiditworked well
27%
saidit'sa big hassle

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Side effects
18possible side effects
  • Headache
    42%
  • Dizziness
    9%
  • Nausea
    8%
  • Asthenia
    7%
  • Abdominal Pain
    6%
  • Somnolence
    6%
  • Amnesia
    4%
  • Dysmenorrhea
    4%
  • Paresthesia
    3%
  • Eye pain
    3%
  • Malaise
    2%
  • Anorexia
    2%
  • Depersonalization
    2%
  • Hypesthesia
    2%
  • Tremor
    2%
  • Abnormal Vision
    2%
  • Hyperacusis
    2%
  • Parosmia
    2%
See more detailed side effects
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Dependence and withdrawal
    • Continuous use for 2 weeks or more
  • Driving impairment
    • Alcohol
    • Taking other medicines that make you less alert
    • Less than 7 hours of sleep
  • Abnormal thoughts
    • Undiagnosed psychiatric conditions
  • Sleep driving
    • Taking with alcohol or drugs
  • Serious allergic reactions
  • Risk to fetus
    • Women of childbearing age
    • Breast-feeding
See more detailed risks and warnings