Compare Sonata vs. Silenor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Helps you fall sleep.

Sonata (zaleplon) aids in falling asleep, but it's not as good with helping you stay asleep or with waking up in the middle of the night.

2.9/ 5 average rating with 175 reviewsforSonata
Helps you relax, and sleep.

Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.

  • Effectively helps people fall asleep faster.
  • Doesn't last as long in the body like some other sleep medicines, so it may cause less side effects the next morning.
  • Generic is available, so it's affordable.
  • In a clinical trial Doxepin was able to significantly improve sleep quality.
  • Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
  • Once your body gets used to Doxepin, most of the side effects go away.
  • Doxepin comes in a generic form, so it is pretty cheap.
  • Doxepin is not addictive.
  • Not typically used for long-term treatment because it can be habit-forming and hasn't been shown to be effective for chronic insomnia.
  • Doesn't last as long in the body as other sleep medicines, so it's not as good at helping you stay asleep.
  • Not recommended if you can't sleep at least 7-8 hours a night.
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
  • Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
  • Doxepin can increase your appetite, leading to weight gain.
  • Taking Doxepin can make emptying your bladder difficult.
  • Some people have suicidal thoughts when taking Doxepin.
  • Doxepin can interact with many different medications, vitamins, and alternative treatments.
Used for
  • Alcoholism - Anxiety - Depression Anxiety - Depression Anxiety - Depression - Psychoneurotic personality disorder Insomnia Pruritus (Moderate)
  • Due to atopic dermatitis or lichen simplex chronicus
  • Urticaria
Dosage forms
  • Pill
  • Pill
  • Liquid
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175 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

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Side effects
18possible side effects
  • Headache
  • Dizziness
  • Nausea
  • Lack of energy
  • Abdominal pain
  • Sleepiness
  • Memory problems
  • Menstrual cramps
  • Burning/prickling sensation
  • Eye pain
  • Malaise
  • Loss of appetite
  • Feelings of detachment
  • Decreased touch sensations
  • Tremor
  • Abnormal vision
  • Increased sensitivity to sound
  • Smell disorder
See more detailed side effects
The Silenor (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Dependence and withdrawal
    • Continuous use of Sonata (zaleplon) for 2 weeks or more
  • Hangover feeling the next day
    • Alcohol
    • Taking other medications that make you less alert
    • Less than 7 hours of sleep
  • CNS depressants and abnormal thoughts
    • Undiagnosed psychiatric conditions
  • Performing activities while asleep
    • Taking Sonata (zaleplon) with alcohol or drugs that cause drowsiness
  • Serious allergic reactions
  • Pregnancy and breastfeeding
    • Women of childbearing age
    • Breastfeeding
See more detailed risks and warnings
No information currently available