Compare Spectracef vs. penicillin

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Spectracef (cefditoren)

Prescription only
Treats bacterial infections.

Spectracef (cefditoren) is good for treating many bacterial infections and it works best if you take the full course without stopping.

Treats bacterial infections.

Penicillin VK (penicillin) is good at treating strep throat and is cheap, however, it can only be used for certain infections as many bacteria have developed resistance to it.

3.9/ 5 average rating with 1297 reviewsforpenicillin
  • Spectracef (cefditoren) can be taken with birth control pills.
  • People usually have few side effects when taking Spectracef (cefditoren).
  • Spectracef (cefditoren) is available as a generic.
  • Compared to alternatives, Penicillin VK (penicillin) is the preferred choice for treating strep throat infections.
  • This medicine is available as a generic, which is cheap.
  • It’s also available in different forms: pill and liquid.
  • Spectracef (cefditoren) can interact with blood thinners and make you more likely to bleed.
  • You can't take Spectracef (cefditoren) and antacids at the same time. Your pharmacist can help you figure out when the best time to take your antacids is.
  • If you're diabetic, Spectracef (cefditoren) can cause a false positive result if you're using Clinitest to measure your urine sugar levels. Talk to your doctor about alternative urine sugar tests.
  • Spectracef (cefditoren) can also affect other lab test so let your physicians know that you're taking Spectracef (cefditoren).
  • Many bacteria are resistant to Penicillin VK (penicillin), so it only works for certain infection typically in ear, nose, and throat.
  • Penicillin VK (penicillin) has a bitter taste. Children might not like the taste.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
No pricing information available
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Side effects
The Spectracef (cefditoren) FDA package insert doesn’t have numbers about how common side effects are.
The Penicillin VK (penicillin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Risk of bleeding
    • Poor nutritional state
    • Prolonged treatment
    • Liver disease
    • Kidney disease
    • Anticoagulant therapy
  • Penicillin allergy
    • History of penicillin allergy
  • New infection
    • Taking Spectracef (cefditoren) for a long time
  • Milk protein allergy
  • Low carnitine levels
    • Carnitine deficiency
    • Kidney damage
    • Kidney disease
    • Low muscle mass
  • Diarrhea
See more detailed risks and warnings
  • Diarrhea
    • Taking Penicillin VK (penicillin) for a long time
  • Interaction with birth control pills
  • Allergic reaction
    • History of severe allergic reaction to Penicillin VK (penicillin)
    • Cephalosporin medication allergy
See more detailed risks and warnings