Compare spironolactone vs. digoxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lanoxin (digoxin)

Prescription only
Removes extra water from your body.

Aldactone (spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.

Improves heart pumping.

Lanoxin (digoxin) is effective at treating heart failure symptoms, but it doesn't lower your risk of death compared to other heart failure medicines.

3.3/ 5 average rating with 70 reviewsfordigoxin
Upsides
  • Has a low risk of causing muscle problems from low potassium levels in your blood.
  • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
  • Can lower blood pressure.
  • Reduces the risk of death in people with heart failure.
  • Lanoxin (digoxin) is used for abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
  • Lanoxin (digoxin) does not need dose adjustments with people with liver problems.
  • Lanoxin (digoxin) is available in a generic form.
  • Lanoxin (digoxin) can be taken once daily.
Downsides
  • Aldactone (spironolactone) doesn't work well on its own. It should be used with another drug to help get rid of excess fluids.
  • Has many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
  • Lanoxin (digoxin) relieves heart failure symptoms, but doesn't lower your risk of death. It's usually used together with other medicines that help lower the risk of death in heart failure.
  • Use of Lanoxin (digoxin) requires blood tests, especially during the first few weeks of treatment to monitor drug level in the body.
  • If your blood levels of Lanoxin (digoxin) are too high, it can be life threatening.
  • Lanoxin (digoxin) is usually not an option for people with kidney problems.
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Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
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70 reviews so far
64%
saidit'sworth it
43%
saiditworked well
31%
saidit'sa big hassle

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Side effects
The Aldactone (spironolactone) FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Dizziness
    5%
  • Mental disturbances
    4%
  • Nausea
    3%
  • Diarrhea
    3%
  • Headache
    3%
  • Death
    3%
  • Increased heart rate
    2%
  • Vomiting
    2%
  • Rash
    2%
See more detailed side effects
Risks and risk factors
  • Tumor development
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
  • Heart problems from high potassium
    • Current kidney problems
    • Taking other medicines that increase potassium
    • Use of salt substitutes
  • Breast pain or swelling
See more detailed risks and warnings
  • Irregular heartbeat
    • History of heart problems
    • Drug interactions
    • Wolff-Parkinson-White syndrome
  • Digoxin toxicity
    • Low body weight
    • Elderly (>65 years old)
    • Worsening kidney function
    • Electrolyte imbalances
  • Thyroid imbalance
    • Overactive or underactive thyroid
See more detailed risks and warnings