Compare Starlix vs. Glyset

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Starlix (nateglinide)

Prescription only

Glyset (miglitol)

Prescription only
Lowers blood sugar.

Starlix (nateglinide) can quickly lower your blood sugar, but needs to be timed with your meals.

Lowers blood sugar.

Glyset (miglitol) controls your blood sugar, but the side effects and how you're supposed to take it can make it hard to take every day.

  • Can quickly lower blood sugar.
  • Good alternative if you have poor kidney function.
  • Can be safely used in people 65 and older.
  • Widely available in generic (cheaper) form.
  • Glyset (miglitol) controls post-meal time blood sugars and does not cause weight gain.
  • Glyset (miglitol) doesn't cause low blood sugar as much as other similar medications.
  • Safe for people 65 years and older.
  • Glyset (miglitol) won't increase your risk of bone fractures like some other antidiabetic drugs.
  • Take during mealtime.
  • May need to take as often as three times daily.
  • Can easily cause hypoglycemia (low blood sugar) if you don't maintain a consistent diet or exercise schedule.
  • Glyset (miglitol) isn't a first choice medication because it doesn't lower blood sugar as well as others.
  • You have to take Glyset (miglitol) 3 times a day with each meal.
  • Glyset (miglitol) can cause diarrhea, excessive gas, and stomach pain when you first start taking it.
  • Not recommended for children under 18.
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
10possible side effects
  • Common cold
  • Back pain
  • Flu symptoms
  • Dizziness
  • Joint problems
  • Diarrhea
  • Accidental trauma
  • Inflammation of the airways
  • Coughing
  • Low blood sugar
See more detailed side effects
The Glyset (miglitol) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Low blood sugar (hypoglycemia)
    • Changes in meal pattern
    • Changes in how much exercise you do
    • Taking other antidiabetic medications
    • Bad liver or renal function
See more detailed risks and warnings
  • Severely low blood sugar (hypoglycemia)
    • Use of other blood sugar-lowering medications
    • Unstable kidney function
  • Kidney problems
    • History of kidney problems
  • Stomach and intestine problems
    • Inflammatory bowel disease
    • Ulcers
    • Bowel obstruction or blockage
    • Trouble absorbing or digesting food
See more detailed risks and warnings