Compare Suboxone vs. Morphine Sulfate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats opioid addiction.

Suboxone (buprenorphine / naloxone) works well to reduce cravings and treat opioid dependence. It's most effective if you have an addiction to heroin or short-acting opioids.

4.0/ 5 average rating with 35 reviewsforSuboxone
Treats severe pain.

Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.

3.5/ 5 average rating with 541 reviewsforMorphine Sulfate
Upsides
  • Suboxone (buprenorphine / naloxone) works best for people addicted to short-acting opioids or heroin.
  • Your doctor can adjust the dose to a level that controls withdrawal symptoms until you're stable.
  • Suboxone (buprenorphine / naloxone) has fewer side effects and drug interactions compared to other similar medicines.
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
Downsides
  • Suboxone (buprenorphine / naloxone) is not as good for people who are dependent on long-acting opioids or methadone because of the risk of a long withdrawal.
  • Like all opioids, it can cause slowed breathing, coma, and death from overdose, especially if you mix with other depressants, like pain medicine or alcohol.
  • You have to be very careful with your dose. Changing the size or strength of a film can affect the amount of drug absorbed into your body, and could cause under- or over-dosing.
  • The film can cause reduced sensation in your mouth, painful burning tongue, or burning mouth syndrome.
  • The film may not be appropriate for you if you have lung disease.
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
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Used for
Dosage forms
  • Pill
  • Sublingual film
  • Dissolving tablet
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
Price
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Reviews
35 reviews so far
80%
saidit'sworth it
66%
saiditworked well
0%
saidit'sa big hassle

Have you used Suboxone (buprenorphine / naloxone)?

Leave a review
541 reviews so far
55%
saidit'sworth it
43%
saiditworked well
20%
saidit'sa big hassle

Have you used Ms Contin (Morphine Sulfate)?

Leave a review
Side effects
16possible side effects
  • Headache
    36%
  • Withdrawal
    25%
  • Pain
    22%
  • Nausea
    15%
  • Difficulty sleeping
    14%
  • Sweating
    14%
  • Constipation
    12%
  • Stomach pain
    11%
  • Dilation of blood vessels
    9%
  • Chills
    8%
  • Vomiting
    8%
  • Weakness
    7%
  • Infection
    6%
  • Hay fever
    5%
  • Back pain
    4%
  • Diarrhea
    4%
See more detailed side effects
The Ms Contin (Morphine Sulfate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Low blood pressure
    • Cardiovascular disease
    • dehydration
    • taking drugs that lower blood pressure
  • Liver failure
    • Liver disease
    • Hepatitis B and C
    • Taking Suboxone (buprenorphine / naloxone) with other drugs that cause liver damage
  • Severe allergic reactions
  • Respiratory depression
    • Taking with alcohol or other drugs that slow the nervous system
    • Lung disease
  • Unintentional child exposure
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
  • Death from overdose
    • Children age 18 and younger
  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Low blood pressure
    • Age 65 years or older
See more detailed risks and warnings