Compare Sudafed vs. Nyquil Cold And Flu
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Sudafed (Pseudoephedrine) relieves stuffy nose, but it could keep you up at night. Don't forget your photo ID or you won't be able to buy it in the drugstore.
Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
- One of the best over-the-counter options to clear stuffy nose and help you breathe better.
- Clears nasal congestion better than other decongestants like phenylephrine.
- Can be helpful in relieving congestion-related headaches and pressure in your ears.
- Available in regular and extended release forms.
- Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
- The cough medicine (dextromethorphan) works well and has very few side effects.
- The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
- The antihistamine (doxylamine) will help you sleep.
- Pseudoephedrine (a decongestant) can make your heart race or make you feel anxious and restless.
- It can affect the quality of your sleep, so you can't take it too close to going to bed.
- Can raise blood pressure so check with your doctor before using it if you have high blood pressure or other heart conditions.
- Sudafed (Pseudoephedrine) isn't as effective after using it for more than 4 days straight.
- Need to show a photo ID to buy it in the drugstore and there is a limit on how much you can buy each visit.
- If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
- You shouldn't use it if you have high blood pressure.
- To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
- Extended release
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- High blood pressure
- History of high blood pressure
- Heart problems
- History of heart problems
- Age 65 years or older
- History of seizures
- Harm to fetus
- Women of childbearing age
- Liver damage
- Drinking more than 2 alcoholic beverages a day
- Taking with other Tylenol-containing medicines
- History of liver disease
- Serotonin syndrome
- Using other medications that affect serotonin
- Driving impairment
- Taking with alcohol
- Taking with other medicines that make you less alert
- Antihistamine side effects
- Age 65 years or older
- Benign prostatic hypertrophy (BPH)