Compare Surmontil vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Surmontil (trimipramine)

Prescription only

Pamelor (nortriptyline)

Prescription only
Improves your mood.

Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.

Improves mood.

Pamelor (nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain, but may take 6 to 8 weeks to feel the full effects on your mood.

4.0/ 5 average rating with 19 reviewsforPamelor
Upsides
  • Surmontil (trimipramine) is part of the first choice medicines to treat depression.
  • Available in generic and in three different strengths.
  • Can be taken once a day, usually before you go to bed.
  • Can be taken with or without food.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Available as a generic in 2 different forms: capsule and liquid.
Downsides
  • You might not notice changes in your mood until you've taken Surmontil (trimipramine) for several weeks.
  • Stopping Surmontil (trimipramine) suddenly without telling your doctor can be dangerous.
  • Surmontil (trimipramine) can cause more side effects than other medicines used to treat depression.
  • Side effects are usually manageable, but can be annoying.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
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Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
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19 reviews so far
79%
saidit'sworth it
79%
saiditworked well
21%
saidit'sa big hassle

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Side effects
The Surmontil (trimipramine) FDA package insert doesn’t have numbers about how common side effects are.
The Pamelor (nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of suicide
    • People under age 24
  • Possible bipolar disorder
  • Serotonin syndrome
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
    • SSRI antidepressants
  • Heart problems
    • History of heart disease
  • Drowsiness or sleepiness
  • Withdrawal symptoms
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
    • Changing the dose
  • Dizziness and falls
    • Age 65 years or older
    • Other blood pressure lowering medications
  • Eye problems
    • Glaucoma
  • Rare, life-threatening
    • Antidepressants
    • Lithium
    • Triptans
    • St. John's wort
    • Fentanyl
    • Tramadol
    • MAO inhibitors
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings