Compare Sustiva vs. delavirdine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Works with other medicines to treat HIV infection.

Sustiva (efavirenz) is one of the most widely used and effective components of an HIV medication regimen. However, it is not a first-line choice because it can have a lot of side effects.

Treats HIV infection.

Rescriptor (delavirdine) is a good alternative, but it's not a first-choice medicine due to its 3 times a day dosing and is not as effective compared to other HIV medications.

Upsides
  • If first-line choices for HIV medications are not an option, Sustiva (efavirenz) would be a good alternative to consider.
  • Only taken once daily.
  • Sustiva (efavirenz) is available in combination tablets.
  • Can be used in patients with mild to moderate kidney damage.
  • Can be used in children who are at least 3 months old.
  • People with mild to moderate kidney damage can use this medication.
  • Can take with or without food.
  • Can crush pill form and mix with water if you have trouble swallowing.
Downsides
  • Not suggested for women who plan on becoming pregnant.
  • Many people exerience intolerable side effects (eg. insomnia, dizziness, abnormal dreams, confusion), which make it hard to take the medication regularly.
  • Cannot be taken alone for treatment of HIV.
  • Doesn't prevent disease transmission, so you must use a condom during sex.
  • Must take at least 1 hour before or after antacids or didanosine.
  • There are multiple drug interactions with Rescriptor (delavirdine), so you must talk to your doctor before starting any new medications.
  • Have to take 3 times a day, so may not be convenient for some people.
  • Cannot use as part of an initial HIV regimen and only use in combination with other HIV medications.
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Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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Side effects
19possible side effects
  • Skin rash
    16%
  • Diarrhea
    14%
  • Pain
    13%
  • Nausea
    10%
  • Dizziness
    9%
  • Itching
    9%
  • Fatigue
    8%
  • Headache
    8%
  • Insomnia
    7%
  • Vomiting
    6%
  • Trouble concentrating
    5%
  • Depression
    5%
  • Indigestion
    4%
  • Anxiety
    4%
  • Abnormal dreams
    3%
  • Abdominal pain
    3%
  • Sleepiness
    2%
  • Nervousness
    2%
  • Loss of appetite
    2%
See more detailed side effects
1possible side effects
  • Skin rash
    35%
See more detailed side effects
Risks and risk factors
  • Central nervous system (CNS) effects
    • Starting Sustiva (efavirenz) for the first few weeks.
    • Taking alcohol or other drugs that also affect your nervous system
  • Fat redistribution
    • HIV treatment
  • Liver damage
    • History of liver damage
    • Alcohol intake
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Psychiatric effects
    • History of mental illness
    • History of substance abuse
  • Rash
    • History of severe skin reactions
    • Children
See more detailed risks and warnings
  • Drug interactions
    • Concurrent use of multiple medications
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Fat redistribution
    • HIV treatment
  • Skin rash
    • History of severe skin reactions
  • Resistance/Cross-resistance
See more detailed risks and warnings