Compare Symproic vs. Colace

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Symproic (naldemedine)

Prescription only

Colace (docusate)

Relieves constipation caused by opiate pain medications.

Symproic (naldemedine) quickly relieves constipation caused by opioids without affecting pain relief, but it can be expensive.

Softens your stools.

Colace (docusate) softens the stool, but may not stimulate a bowel movement as quickly as a laxative.

3.6/ 5 average rating with 125 reviewsforColace
  • Symproic (naldemedine) is a good option if traditional laxatives have not worked for you.
  • You only have to take Symproic (naldemedine) once a day.
  • Symproic (naldemedine) doesn't affect how opioids treat pain.
  • It works much faster than most other laxatives.
  • It does not have to be dose adjusted if you have kidney problems.
  • Safer than laxatives.
  • Available over-the-counter.
  • Safe to use in children as young as 2 years old.
  • Symproic (naldemedine) is not available as a cheaper generic form.
  • It is more expensive than traditional axatives.
  • This medication is not a good option if you have severe liver problems.
  • May take up to 5 days for the full effects to kick in.
  • Intended to be used only as a short-term solution for occasional constipation. Other options such as fiber supplements may be more useful for maintaining regular bowel movements.
Used for
  • Opioid-induced constipation
Dosage forms
  • Pill
  • Pill
  • Enema
  • Liquid
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125 reviews so far
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Side effects
4possible side effects
  • Stomach pain
  • Diarrhea
  • Nausea
  • Stomach flu
See more detailed side effects
The Colace (docusate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Opioid withdrawal and reduced pain relief
  • Stomach or intestinal holes
    • Crohns disease
    • Peptic ulcer disease
    • Diverticular disease
    • Stomach malignancies
    • Ogilvie’s syndrome
See more detailed risks and warnings
  • Complete or partial blockage of intestines
See more detailed risks and warnings