Compare Tagamet vs. Alka-Seltzer

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats heartburn.

Tagamet (cimetidine) works well for heartburn, but may have more side effects than other medicines like it.

3.4/ 5 average rating with 632 reviewsforTagamet
Relieves symptoms of indigestion and pain

Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) provides quick relief for heartburn, upset stomach, headaches, and general pain. However, you have to take it a few times a day to continue getting relief of your symptoms.

3.9/ 5 average rating with 1055 reviewsforAlka-Seltzer
Upsides
  • Lasts longer than other medicines like it so you may not need to take it as frequently.
  • Affordable as an over-the-counter or generic medicine.
  • Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) is a great option if you have an upset stomach and a headache or body aches at the same time.
  • Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) works quickly to relieve symptoms.
  • Available over the counter without a prescription.
  • Also, available as generic and is fairly cheap.
Downsides
  • Does not work as fast as antacids like Maalox, Tums, or Rolaids.
  • May not work as well if you have an inflammed esophagus. Your doctor will assess which medicine is best for you.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • Can interfere with how other medicines work.
  • The effects of this medication don't last very long. Other medicines, like Zantac (H2 blockers) and omeprazole (proton pump inhibitors), work better and last longer.
  • Because this medicine contains aspirin, it raises the risk of bleeding, especially if you take any other blood thinning medicines.
  • People who are allergic to aspirin can't use this medication.
  • May not like the taste or fizz.
  • Kids or teenagers should not use Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) unless instructed by a doctor.
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Used for
Dosage forms
  • Pill
  • Liquid
  • Effervescent tablet
Price
No pricing information available
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Reviews
632 reviews so far
63%
saidit'sworth it
36%
saiditworked well
12%
saidit'sa big hassle

Have you used Tagamet (cimetidine)?

Leave a review
1055 reviews so far
81%
saidit'sworth it
52%
saiditworked well
8%
saidit'sa big hassle

Have you used Alka-Seltzer (aspirin / citric acid / sodium bicarbonate)?

Leave a review
Side effects
The Tagamet (cimetidine) FDA package insert doesn’t have numbers about how common side effects are.
The Alka-Seltzer (aspirin / citric acid / sodium bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Confusion
    • Elderly
    • Kidney problems
    • Liver problems
    • Dementia
  • Drug interactions
  • Chronic lung problems
    • Asthma
    • COPD
    • Lung problems
  • Clostridium difficile associated diarrhea
    • Taking antibiotics
  • Englarged breasts in men (gynecomastia)
See more detailed risks and warnings
  • Taking the wrong medication
    • Not reading the drug label
  • Brain damage or death from Reye's Syndrome
    • Children 18 years or younger recovering from viral infections
  • High blood sodium levels
    • Current kidney disease
    • Dialysis
    • Age 65 or older
    • Hyperparathyroidism
    • Use of other medicines that can cause kidney damage
  • May worsen heart or kidney problems
    • Congestive heart failure (CHF)
    • High blood pressure
    • Current kidney disease
    • Kidney dialysis
  • Stomach Bleeding
    • History of stomach bleeding or ulcers
    • Age 60 or older
    • Also taking other blood thinners
    • Drinking 3 or more alcoholic drinks a day
  • Harm to unborn babies
    • Pregnancy
See more detailed risks and warnings