Compare Tegretol vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Tegretol (Carbamazepine)

Prescription only

Depakote (divalproex)

Prescription only
Prevents seizures, stabilizes mood, and relieves nerve pain.

Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.

3.3/ 5 average rating with 61 reviewsforTegretol
Treats and prevents seizures, and stabilizes mood.

Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.

3.3/ 5 average rating with 97 reviewsforDepakote
Upsides
  • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
  • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
  • May be helpful in stabilizing mood for people with bipolar disorder.
  • Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
  • Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
  • Depakote (divalproex) is helpful for preventing frequent migraines.
  • The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
  • Depakote (divalproex) is available as a generic.
Downsides
  • Interacts with many other medicines and supplements.
  • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
  • Can cause blurry vision, dizziness, and upset stomach.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
  • Depakote (divalproex) is not a good medication for people with liver problems.
  • Requires regular blood tests to see how the medication is affecting your body.
  • Depakote (divalproex) can make you bleed more easily.
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Used for
Dosage forms
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
  • Pill
  • Extended release pill
  • Delayed release pill
Price
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Reviews
61 reviews so far
56%
saidit'sworth it
43%
saiditworked well
23%
saidit'sa big hassle

Have you used Tegretol (Carbamazepine)?

Leave a review
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

Have you used Depakote (divalproex)?

Leave a review
Side effects
18possible side effects
  • Dizziness
    44%
  • Somnolence
    32%
  • Nausea
    28%
  • Vomiting
    18%
  • Ataxia
    15%
  • Constipation
    10%
  • Pruritus
    8%
  • Dry Mouth
    8%
  • Asthenia
    8%
  • Rash
    7%
  • Blurred vision
    6%
  • Speech Disorder
    6%
  • Hypertension
    3%
  • Tremor
    3%
  • Paresthesia
    2%
  • Thinking abnormal
    2%
  • Twitching
    2%
  • Vertigo
    2%
See more detailed side effects
9possible side effects
  • Nausea
    22%
  • Sleepiness
    19%
  • Dizziness
    12%
  • Vomiting
    12%
  • Accidental injury
    11%
  • Feeling weak
    10%
  • Abdominal pain
    9%
  • Upset stomach
    9%
  • Rash
    6%
See more detailed side effects
Risks and risk factors
  • Serious skin rash
    • People also taking Depakote
    • Asian ancestry
  • Blood disorders
  • Suicidal thoughts or behavior
    • History of depression
  • Serious allergic reactions
    • European, Chinese, or Japanese ancestry
  • Pregnancy
  • Mental changes due to low sodium
    • Age 65 years or older
  • Withdrawal seizures
    • Stopping Tegretol (Carbamazepine) suddenly
See more detailed risks and warnings
  • Harm to fetus
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
    • Severe seizure disorder
    • Brain disease
    • History of liver problems
  • Pancreas problems
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes
    • History of metabolic disorders
    • People also taking Topamax
See more detailed risks and warnings