Compare Tegretol vs. Zonegran

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Tegretol (carbamazepine)

Prescription only

Zonegran (zonisamide)

Prescription only
Treats seizures and epilepsy.

Tegretol (carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but reduces how well many other medications work.

3.3/ 5 average rating with 61 reviewsforTegretol
Controls partial seizures.

Zonegran (zonisamide) is used with other medicines to help control partial seizures. It can't be used by itself.

Upsides
  • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
  • First-choice option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
  • Equetro is helpful in stabilizing mood for people with bipolar disorder.
  • Available as a generic in many forms: pill, extended-release pill, suspension, and chewable tablet.
  • Available in generic.
  • Can be given once a day, so it's easier to remember.
  • You can take Zonegran (zonisamide) with or without food.
Downsides
  • Takes several weeks to feel the full effects.
  • Interacts with many other medicines and supplements.
  • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Can't take the suspension form with other liquid medications.
  • Zonegran (zonisamide) has to be used with other medicines to help control your seizures. It's not used by itself.
  • Zonegran (zonisamide) is only approved in people age 16 or older.
  • Zonegran (zonisamide) can cause kidney stones; so you have to make sure you drink plenty of liquids.
  • Zonegran (zonisamide) can weaken your bones. Talk to your doctor about how to keep your bones strong.
  • Other medicines used to control seizures can interact with Zonegran (zonisamide), so your doctor might have to change the dosing of your medications.
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Used for
Dosage forms
  • Pill
  • Extended-release pill
  • Suspension
  • Chewable tablet
  • Pill
Price
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Reviews
61 reviews so far
56%
saidit'sworth it
43%
saiditworked well
23%
saidit'sa big hassle

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Side effects
The Tegretol (carbamazepine) FDA package insert doesn’t have numbers about how common side effects are.
34possible side effects
  • Sleepiness
    17%
  • Loss of appetite
    13%
  • Dizziness
    13%
  • Headache
    10%
  • Nausea
    9%
  • Agitation or Irritability
    9%
  • Fatigue
    8%
  • Tiredness
    7%
  • Stomach pain
    6%
  • Difficulty controlling movements
    6%
  • Confusion
    6%
  • Difficulty with concentration
    6%
  • Difficulty with memory
    6%
  • Depression
    6%
  • Trouble sleeping
    6%
  • Double vision
    6%
  • Diarrhea
    5%
  • Speech difficulties
    5%
  • Flu
    4%
  • Difficulty controlling eye movements
    4%
  • Prickling and tingling sensation
    4%
  • Mental slowing
    4%
  • Upset stomach
    3%
  • Weight loss
    3%
  • Anxiety
    3%
  • Skin rash
    3%
  • Constipation
    2%
  • Dry mouth
    2%
  • Bruising
    2%
  • Nervousness
    2%
  • Schizophrenia-like behavior
    2%
  • Difficulties in verbal expression
    2%
  • Stuffy nose
    2%
  • Changes in taste
    2%
See more detailed side effects
Risks and risk factors
  • Life-threatening skin reactions
    • Carrying HLA-B*1502 gene
    • Asian ancestry
  • Blood disorders
  • Suicidal thoughts or behavior
    • History of depression
  • Serious allergic reactions
    • History of allergic reaction to Trileptal (oxcarbamazepine)
  • Pregnancy
  • Mental changes due to low sodium
    • Age 65 or older
    • Dehydration
    • Taking diuretics (water pills)
See more detailed risks and warnings
  • Sulfa medicine allergy
    • Allergy to sulfonamides such as Septra or Bactrim
  • Lower blood cell counts
  • Heat stroke and less sweating
    • Under age 18
  • Suicidal behavior
    • Taking other medicines to control seizures
  • Higher blood acid
    • Diarrhea
    • Kidney disease
    • Severe COPD or lung disease
  • Withdrawal seizures
See more detailed risks and warnings