Compare Tetracycline vs. benzoyl peroxide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Benzac (benzoyl peroxide)

Prescription or OTC
Kills bacteria and treats acne.

Acnecycline (Tetracycline) treats many different types of infections and is cheap, but dosing and drug interactions may be somewhat of a hassle.

3.3/ 5 average rating with 153 reviewsforTetracycline
Treats acne.

Benzac (benzoyl peroxide) is the most effective over-the-counter treatment for mild acne.

3.4/ 5 average rating with 394 reviewsforbenzoyl peroxide
Upsides
  • Effectively treats a wide range of conditions and is used for many different types of infections.
  • Effective for acne.
  • Cheap.
  • Good choice for people on kidney dialysis who need an antibiotic. Tetracycline isn't removed by dialysis, so the dose doesn't need to be changed.
  • Available over-the-counter from many brands.
  • Benzac (benzoyl peroxide) comes in many different forms and combinations with other acne products.
Downsides
  • For most infections you'll need to take it 4 times a day (or every 6 hours).
  • It needs to be spaced out from food, milk, vitamins, and some medications.
  • Can cause tongue darkening, heartburn, nausea, vomiting, and diarrhea.
  • Tetracycline makes your skin more sensitive to the sun and ultraviolet light. Wear sunblock and protective clothing, and don't go tanning.
  • Interacts with birth control and makes it less effective. Use a backup form of birth control if you don't want to get pregnant.
  • Not a good choice for children ages 8 and under. Tetracycline can cause permanent staining of teeth in babies and young children.
  • Benzac (benzoyl peroxide) increases your skin's sensitivity to the sun and may also cause dryness or stinging.
  • Be careful when applying Benzac (benzoyl peroxide) to large areas since it can bleach hair, clothing, and pillow cases upon contact.
  • Benzac (benzoyl peroxide) needs to be combined with other medications to effectively treat severe acne.
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Used for
Dosage forms
  • Pill
  • Cream, gel, or ointment
  • Cream
  • Lotion
  • Liquid
  • Gel
  • Foam
  • Soap
Price
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Reviews
153 reviews so far
45%
saidit'sworth it
29%
saiditworked well
16%
saidit'sa big hassle

Have you used Acnecycline (Tetracycline)?

Leave a review
394 reviews so far
60%
saidit'sworth it
29%
saiditworked well
9%
saidit'sa big hassle

Have you used Benzac (benzoyl peroxide)?

Leave a review
Side effects
The Acnecycline (Tetracycline) FDA package insert doesn’t have numbers about how common side effects are.
The Benzac (benzoyl peroxide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Changes in teeth
    • Pregnancy
    • Age younger than 8 years
  • Reduced effectiveness of birth control pills
  • Decreased kidney function and kidney injury
    • Kidney disease
    • Taking Acnecycline (Tetracycline) past the expiration date
  • Sunburn
    • Exposure to sunlight or ultraviolet light
  • Harm to fetus
    • Women of childbearing age
  • Increased pressure in the brain
    • Taking with Acnecycline (Tetracycline) with other medicines that can cause this effect (e.g. Accutane)
  • Liver injury
    • Kidney disease
    • Large doses of Acnecycline (Tetracycline)
  • Development of more serious infections
    • Long-term use of Acnecycline (Tetracycline)
See more detailed risks and warnings
  • Bleaching
  • Skin irritation
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
  • Allergic reaction
See more detailed risks and warnings