Compare thiothixene vs. thioridazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Navane (thiothixene)

Prescription only

Mellaril (thioridazine)

Prescription only
Treats schizophrenia.

Navane (thiothixene) isn't a first choice for treating schizophrenia because of the side effects, but it is cheaper than other medicines.

Treats schizophrenia.

Taking Mellaril (thioridazine) is one of many options to treat schizophrenia if other medicines haven't worked, but there are some side effects which can be dangerous.

Upsides
  • Navane (thiothixene) is available in generic.
  • Navane (thiothixene) is less likely to make you sleepy.
  • Available in generic.
  • Compared to other similar medicines, Mellaril (thioridazine) is less likely to cause problems controlling your movements.
Downsides
  • Side effects include weight gain and high blood sugar.
  • Navane (thiothixene) can cause low blood pressure, which can cause fainting or falls if you’re not careful.
  • Smoking tobacco can make Navane (thiothixene) work poorly.
  • Mellaril (thioridazine) is only recommended for schizophrenia if other medicines haven't worked because the side effects can be very dangerous.
  • You have to take Mellaril (thioridazine) numerous times a day which can make it hard to remember.
  • Mellaril (thioridazine) can interfere with your heartbeat, so your doctor might have you do annual tests with your heart to make sure it's healthy.
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Dosage forms
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Price
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Reviews
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Side effects
The Navane (thiothixene) FDA package insert doesn’t have numbers about how common side effects are.
The Mellaril (thioridazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
  • Drowsiness and sleepiness
    • Drinking alcohol, or taking opioids, benzodiazepines, or sleeping medicines
  • Low blood pressure
See more detailed risks and warnings
  • Problems with the heartbeat
    • History of heartbeat problems
    • Taking medicines for depression
    • Taking beta blockers
  • Increased risk of death in elderly people with dementia
    • People older than 65 years with dementia and psychosis
  • Difficulty controlling movements
    • Long-term use of Mellaril (thioridazine)
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Sleepiness and risk of falls
    • Drinking alcohol or taking narcotics
  • Decreased white blood cells
    • History of low white blood cells
See more detailed risks and warnings