Compare thiothixene vs. trifluoperazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Navane (thiothixene)

Prescription only
Treats schizophrenia.

Navane (thiothixene) isn't a first choice for treating schizophrenia because of the side effects, but it is cheaper than other medicines.

Treats anxiety and schizophrenia.

Stelazine (trifluoperazine) can be used to treat schizophrenia, but you might have trouble controlling your movements.

Upsides
  • Navane (thiothixene) is available in generic.
  • Navane (thiothixene) is less likely to make you sleepy.
  • Stelazine (trifluoperazine) is one of the recommended medicines for schizophrenia.
  • It’s approved in children age 6 and older.
  • Available in generic.
  • Compared to other similar medicines, you're less likely to feel dehydrated or have problems with your heart with Stelazine (trifluoperazine).
Downsides
  • Side effects include weight gain and high blood sugar.
  • Navane (thiothixene) can cause low blood pressure, which can cause fainting or falls if you’re not careful.
  • Smoking tobacco can make Navane (thiothixene) work poorly.
  • If you take Stelazine (trifluoperazine) for more than 12 weeks or are taking high doses of Stelazine (trifluoperazine), you’re at a higher risk for being unable to control your movements.
  • Stelazine (trifluoperazine) can cause agitation and trouble sleeping. These symptoms can sometimes disappear, or there are other treatments you can take to help.
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Reviews
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Side effects
The Navane (thiothixene) FDA package insert doesn’t have numbers about how common side effects are.
The Stelazine (trifluoperazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
  • Drowsiness and sleepiness
    • Drinking alcohol, or taking opioids, benzodiazepines, or sleeping medicines
  • Low blood pressure
See more detailed risks and warnings
  • Higher risk of death in people age 65 and older with dementia
    • People age 65 and older with dementia and psychosis
  • Difficulty controlling movements
    • Women age 65 and older
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Changes in blood cell counts
    • History of low white or red blood cell counts
  • Liver damage
  • Low blood pressure and higher risk of falls
See more detailed risks and warnings