Compare Toujeo vs. metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Toujeo (insulin glargine)

Prescription only

Glucophage (metformin)

Prescription only
Lowers blood sugar.

Toujeo (insulin glargine) is a concentrated long-actin insulin that allows you to inject higher doses at lower volume compared to other long-acting insulins like Lantus and Levemir.

Lowers blood sugar.

Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.

3.7/ 5 average rating with 938 reviewsformetformin
Upsides
  • Most effective medicine for controlling your blood sugar.
  • Can be injected once daily.
  • Contains 3 times as much insulin as other long-acting insulins, which means that you can inject lower fluid volume.
  • Can be used in patients 65 and older.
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
Downsides
  • Has to be injected.
  • Can cause weight gain like other insulins
  • Can cause low blood sugar (hypoglycemia), especially if you do not take it consistently or have an inconsistent meal and exercise schedule.
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
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Used for
Dosage forms
  • Injection
  • Pill
  • Extended release pill
  • Liquid
Price
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Reviews
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938 reviews so far
65%
saidit'sworth it
46%
saiditworked well
16%
saidit'sa big hassle

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Side effects
3possible side effects
  • Hypoglycemia (low blood sugar)
    69%
  • Common cold
    13%
  • Lung infection
    10%
See more detailed side effects
7possible side effects
  • Diarrhea
    53%
  • Nausea/vomiting
    26%
  • Gas
    12%
  • Weakness
    9%
  • Indigestion
    7%
  • Stomach pain
    6%
  • Headache
    6%
See more detailed side effects
Risks and risk factors
  • Sharing of Toujeo (insulin glargine) pens
  • Changes in blood sugar levels
    • Changes in insulin
    • Alcohol
    • Other anti-diabetic medications
  • Medication errors
    • Using more than one insulin at a time
  • Severe allergic reactions
    • Allergic reactions to other insulins
  • Hypoglycemia (low blood sugars)
  • Fluid accumulation leading to heart failure
    • Taking thiazolidinediones in combination with insulin
See more detailed risks and warnings
  • Excess lactic acid in the blood
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use
  • Low vitamin B12 levels
See more detailed risks and warnings