Compare Tradjenta vs. Invokamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lowers blood sugar.

Tradjenta (linagliptin) is good add-on medicine for controlling your blood sugar, but may cause body aches.

Lowers blood sugar.

Invokamet (canagliflozin / metformin) is a combination of 2 medicines that can lower your blood sugars, but it still has to be taken twice daily.

  • Good add-on medicine if your blood sugars are still not controlled
  • Good option if you have bad liver or kidney function.
  • Can be taken once daily.
  • Does not cause weight gain.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
  • Combines 2 effective anti-diabetes medicines into one pill so you don't have to take them separately.
  • Does not cause weight gain unlike other anti-diabetic medicines.
  • Not as likely to cause hypoglycemia (low blood sugar)
  • Not first-choice anti-diabetes medicine because it doesn't lower blood sugar levels as much as others.
  • Available as brand only and may be expensive
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
  • May cause increased urination.
  • More likely to cause broken bones and yeast and urinary tract infections.
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
6possible side effects
  • Back pain
  • Joint pain
  • Lung infection
  • Headache
  • Cough
  • Pain in the limbs
See more detailed side effects
9possible side effects
  • Yeast infection in women
  • Urinary tract infections
  • Increased urination
  • Yeast infection in men
  • Thirst
  • Vaginal itching
  • Constipation
  • Nausea
  • Abdominal pain
See more detailed side effects
Risks and risk factors
  • Inflammation of pancreas (pancreatitis)
    • Alcoholism
    • Elevated triglycerides
    • History of pancreatitis
  • Low blood sugar (hypoglycemia)
    • Alcoholism
    • Exercising more than you usually do
    • Insulin
    • Other antidiabetic medications
  • Severe allergic reactions
  • Severe joint pain
  • Fluid-filled blisters on the skin (bullous pemphigoid)
See more detailed risks and warnings
  • Acid buildup in the blood
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Contrast dye for procedure
    • Surgery
    • Alcohol use
  • Low blood pressure (hypotension)
    • Over age 65
    • Kidney problems
    • Diuretics
    • Taking ACE inhibitors or ARBs
    • Low blood pressure
  • Bone fractures
    • Low blood pressure
    • Weak bones (Osteoporosis)
  • Kidney damage
    • History of kidney damage
    • Heart failure
    • Blood pressure medicines (water pills, ACE inhibitors, ACE inhibitors)
    • Anti-inflammatories (NSAIDs)
  • Genital yeast infection and urinary tract infection
    • History of urinary tract infections
    • History of fungal genital infections
    • Uncircumcised males
  • Low blood sugars
    • Taking other diabetic medications
    • Increased exercise
    • Drinking alcohol
See more detailed risks and warnings