Compare tramadol vs. Percocet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

ADVERTISEMENT
Treats moderate to severe pain.

Ultram (tramadol) works well for pain. Although it's a little weaker than other opioids, it can still be addictive.

3.4/ 5 average rating with 642 reviewsfortramadol
Treats moderate to severe pain.

Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

3.8/ 5 average rating with 1399 reviewsforPercocet
Upsides
  • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
  • Compared to typical opioids, it provides unique pain relief and effects on your mood when taken regularly.
  • Has a lower chance of causing breathing problems compared to other typical opioids.
  • Doesn't cause as much constipation as other opioid pain medicines. Staying hydrated and taking laxatives can help treat this side effect.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides
  • Some people think it's weaker than other opioid pain medications. It can also cause more upset stomach.
  • Like other opioid pain relievers, Ultram (tramadol) has a high risk of addiction, abuse, misuse, overdose, and death.
  • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
  • It's a controlled substance regulated by the federal government. This means that your use of Ultram (tramadol) will be tracked to prevent potential prescription abuse.
  • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
ADVERTISEMENT
Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release capsule
  • Dissolving tablet
  • Pill
  • Oral solution
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
642 reviews so far
61%
saidit'sworth it
40%
saiditworked well
16%
saidit'sa big hassle

Have you used Ultram (tramadol)?

Leave a review
1399 reviews so far
70%
saidit'sworth it
49%
saiditworked well
15%
saidit'sa big hassle

Have you used Percocet (Oxycodone / Acetaminophen)?

Leave a review
Side effects
13possible side effects
  • Dizziness
    26%
  • Nausea
    24%
  • Constipation
    24%
  • Headache
    18%
  • Sleepiness
    16%
  • Vomiting
    9%
  • Pruritus
    8%
  • CNS Stimulation
    7%
  • Asthenia
    6%
  • Sweating
    6%
  • Dyspepsia
    5%
  • Dry Mouth
    5%
  • Diarrhea
    5%
See more detailed side effects
The Percocet (Oxycodone / Acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Breathing problems
    • Age 65 or greater
    • Overdose
    • Using alcohol, benzodiazepines or other medicines that slow breathing
  • Addiction, abuse, and overdose
    • Taking more than the prescribed dose
    • Taking with alcohol or benzodiazepines
    • Stopping Ultram (tramadol) suddenly
  • Interactions with other drugs
  • Withdrawal in newborns
    • Pregnancy
  • Accidental ingestion
    • Children can reach medication
See more detailed risks and warnings
  • Death from liver failure
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen
  • Death from lack of oxygen to the body (respiratory depression)
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Tolerance and dependence
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Neonatal withdrawal syndrome
    • Long-term use of opioids in mother
    • Breastfeeding while taking Percocet (Oxycodone / Acetaminophen)
  • Death from overdose (extended-release tablet)
    • Children age 18 and younger
    • Taking more than prescribed dose
    • Mixing with alcohol or drugs that interact with Percocet (Oxycodone / Acetaminophen)
  • Severe allergic reactions
  • Low blood pressure
    • Age 65 years or older
    • Circulation problems
See more detailed risks and warnings