Compare Trileptal vs. Zonegran

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Trileptal (Oxcarbazepine)

Prescription only

Zonegran (zonisamide)

Prescription only
Prevents seizures.

Trileptal (Oxcarbazepine) is effective at preventing seizures and you don’t need to get regular blood tests to make sure it’s effective, but it has many drug interactions.

Controls partial seizures.

Zonegran (zonisamide) is used with other medicines to help control partial seizures. It can't be used by itself.

Upsides
  • Trileptal (Oxcarbazepine) is effective at lowering the frequency of seizures, especially for people with partial seizures.
  • If you have trouble swallowing tablets, Trileptal (Oxcarbazepine) is also available as an oral solution.
  • You won’t need to get regular blood tests to check the drug levels in your body.
  • Available in a generic form.
  • Available in generic.
  • Can be given once a day, so it's easier to remember.
  • You can take Zonegran (zonisamide) with or without food.
Downsides
  • It’s important to take your dose on time so that Trileptal (Oxcarbazepine) has steady levels in your body.
  • Interacts with many other medicines and supplements.
  • Can cause difficulty concentrating, tiredness or drowsiness, and problems with coordination.
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
  • Being pregnant lowers the levels of Trileptal (Oxcarbazepine), so the medicine might not be as effective at preventing seizures.
  • Zonegran (zonisamide) has to be used with other medicines to help control your seizures. It's not used by itself.
  • Zonegran (zonisamide) is only approved in people age 16 or older.
  • Zonegran (zonisamide) can cause kidney stones; so you have to make sure you drink plenty of liquids.
  • Zonegran (zonisamide) can weaken your bones. Talk to your doctor about how to keep your bones strong.
  • Other medicines used to control seizures can interact with Zonegran (zonisamide), so your doctor might have to change the dosing of your medications.
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Dosage forms
  • Pill
  • Liquid
  • Pill
Price
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Reviews
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Side effects
21possible side effects
  • Dizziness
    22%
  • Nausea
    16%
  • Headache
    13%
  • Any adverse effect
    9%
  • Diarrhea
    7%
  • Vomiting
    7%
  • Upper Respiratory Tract Infection
    7%
  • Constipation
    5%
  • Dyspepsia
    5%
  • Ataxia
    5%
  • Nervousness
    5%
  • Falling Down NOS
    4%
  • Pain Back
    4%
  • Amnesia
    4%
  • Coordination Abnormal
    4%
  • Tremor
    4%
  • Epistaxis
    4%
  • Infection Chest
    4%
  • Sinusitis
    4%
  • Rash
    4%
  • Vision Abnormal
    4%
See more detailed side effects
34possible side effects
  • Sleepiness
    17%
  • Loss of appetite
    13%
  • Dizziness
    13%
  • Headache
    10%
  • Nausea
    9%
  • Agitation or Irritability
    9%
  • Fatigue
    8%
  • Tiredness
    7%
  • Stomach pain
    6%
  • Difficulty controlling movements
    6%
  • Confusion
    6%
  • Difficulty with concentration
    6%
  • Difficulty with memory
    6%
  • Depression
    6%
  • Trouble sleeping
    6%
  • Double vision
    6%
  • Diarrhea
    5%
  • Speech difficulties
    5%
  • Flu
    4%
  • Difficulty controlling eye movements
    4%
  • Prickling and tingling sensation
    4%
  • Mental slowing
    4%
  • Upset stomach
    3%
  • Weight loss
    3%
  • Anxiety
    3%
  • Skin rash
    3%
  • Constipation
    2%
  • Dry mouth
    2%
  • Bruising
    2%
  • Nervousness
    2%
  • Schizophrenia-like behavior
    2%
  • Difficulties in verbal expression
    2%
  • Stuffy nose
    2%
  • Changes in taste
    2%
See more detailed side effects
Risks and risk factors
  • Mental changes due to low sodium
    • Age 65 or older
    • dehydration
    • Taking diuretics (water pills)
  • Serious allergic reactions
    • Had allergic reaction to Tegretol (carbamazepine)
  • Life-threatnening skin reactions
    • Asian ancestry
  • Suicidal thoughts or behavior
    • History of depression
  • Withdrawal seizures
    • Stopping Trileptal (Oxcarbazepine) suddenly
  • Changes in blood cells
  • Bone disorders
    • History of osteoporosis
    • History of fractures
  • Liver problems
  • Low thyroid levels
    • Children
See more detailed risks and warnings
  • Sulfa medicine allergy
    • Allergy to sulfonamides such as Septra or Bactrim
  • Lower blood cell counts
  • Heat stroke and less sweating
    • Under age 18
  • Suicidal behavior
    • Taking other medicines to control seizures
  • Higher blood acid
    • Diarrhea
    • Kidney disease
    • Severe COPD or lung disease
  • Withdrawal seizures
See more detailed risks and warnings