Compare Trizivir vs. Epivir

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats HIV infections.

Trizivir (abacavir / lamivudine / zidovudine) is a convenient 3-in-1 medication used to treat HIV infections. It's not a first choice medication, but it can be an option for you if other HIV medications have not controlled your viral load.

Works with other medicines to treat HIV infection or chronic hepatitis B.

Epivir (lamivudine) is a first-choice and commonly used medicine to take together with other HIV medications to treat HIV. It is also an alternative option for treating chronic hepatitis B.

Upsides
  • Trizivir (abacavir / lamivudine / zidovudine) combines three different HIV medications into one tablet.
  • Is available in generic form.
  • Doesn't affect your kidneys or bone density like some other HIV medications.
  • Epivir (lamivudine) can be used with many other HIV options to create a combination that's right for you.
  • Has very minimal interactions with other medications.
  • Available in tablet and liquid form.
  • Can be take once or twice a day. Also available in different combination pills so you don't have to take as many pills per day.
  • Available in cheaper generic form.
Downsides
  • Trizivir (abacavir / lamivudine / zidovudine) isn't a first choice medication for treating HIV.
  • Trizivir (abacavir / lamivudine / zidovudine) can increase your risk of heart attack.
  • This is not a great medication to take if you have liver or kidney problems.
  • Severe allergic reactions have happened in some patients taking Trizivir (abacavir / lamivudine / zidovudine). Your doctor will test you for any possible risk of reaction before starting Trizivir (abacavir / lamivudine / zidovudine).
  • Cannot take Epivir (lamivudine) by itself to treat HIV.
  • Might need to change dosage based on how well your kidneys function.
  • It is recommended to use other options to treat chronic hepatitis B before choosing Epivir (lamivudine) due to drug resistance.
  • You'll have to be tested for both HIV and hepatitis B, since the dose to treat hepatitis B is lower than the dose for HIV. If you have the lower dose, HIV can be harder to treat if you also have hepatitis B.
  • The liquid version of Epivir (lamivudine) has sugar, so if you have diabetes, your blood sugar levels might change.
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Used for
  • HIV infection
  • Hepatitis B
  • HIV prevention, non-occupational (PEP)
  • HIV prevention, mother-to-child
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
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Side effects
13possible side effects
  • Nausea
    19%
  • Headache
    13%
  • Malaise and fatigue
    12%
  • Nausea and vomiting
    10%
  • Allergic reaction
    8%
  • Diarrhea
    7%
  • Fever and/or chills
    6%
  • Depressive disorders
    6%
  • Musculoskeletal pain
    5%
  • Skin rashes
    5%
  • Ear/nose/throat infections
    5%
  • Viral respiratory infections
    5%
  • Anxiety
    5%
See more detailed side effects
3possible side effects
  • Ear, nose, and throat infections
    25%
  • Diarrhea
    14%
  • Sore throat
    13%
See more detailed side effects
Risks and risk factors
  • Severe allergic reaction
    • Previous allergic reaction to Trizivir, Triumeq or abacavir
    • Presence of HLA-B*5701 gene
  • Blood and bone marrow problems
    • Advanced HIV
    • Anemia
    • Neutropenia
  • Muscle and kidney damage
    • Extended use of Trizivir (abacavir / lamivudine / zidovudine)
  • Rare, serious condtion
    • Liver disease
    • Women
    • Obesity
  • Worsening hepatitis B infection
    • Hepatitis B Virus infection
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
See more detailed risks and warnings
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Acute Exacerbation of Hepatitis B Virus (HBV)
    • Hepatitis B virus
  • Different doses available
  • HIV counseling/testing
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Pancreatitis
See more detailed risks and warnings