Compare Truvada vs. Sustiva

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Works with other medications to treat HIV infection, or works alone to prevent HIV infection.

Truvada (emtricitabine / tenofovir) is a versatile, first-choice HIV medication that is used in combination with other HIV medications to treat and prevent HIV infections.

4.8/ 5 average rating with 16 reviewsforTruvada
Works with other medicines to treat HIV infection.

Sustiva (efavirenz) is one of the most widely used and effective components of an HIV medication regimen. However, it is not a first-line choice because it can have a lot of side effects.

Upsides
  • Contains two first-choice medications which can be used in combination with other drugs to treat HIV infection.
  • Truvada (emtricitabine / tenofovir) is also a first-choice option to be used for preventing HIV.
  • Take only once daily, with or without food.
  • If first-line choices for HIV medications are not an option, Sustiva (efavirenz) would be a good alternative to consider.
  • Only taken once daily.
  • Sustiva (efavirenz) is available in combination tablets.
  • Can be used in patients with mild to moderate kidney damage.
  • Can be used in children who are at least 3 months old.
Downsides
  • If you're taking Truvada (emtricitabine / tenofovir) to stop you from getting HIV, you should continue having safe sex since it won't protect you from other sexually transmitted infections.
  • If you're taking Truvada (emtricitabine / tenofovir) to stop you from getting HIV, you have to get blood tests every 3 months to check for overall health and to make sure you don't have HIV or other sexually transmitted infections.
  • People with poorly functioning kidneys shouldn't take Truvada (emtricitabine / tenofovir).
  • Can weaken your bones.
  • If you have HIV as well as Hepatitis B and stop taking Truvada (emtricitabine / tenofovir) suddenly, your hepatitis may get worse.
  • Not suggested for women who plan on becoming pregnant.
  • Many people exerience intolerable side effects (eg. insomnia, dizziness, abnormal dreams, confusion), which make it hard to take the medication regularly.
  • Cannot be taken alone for treatment of HIV.
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Used for
  • HIV treatment
  • HIV prevention
  • Hepatitis B treatment
Dosage forms
  • Pill
  • Pill
Price
Lowest price
$1672.61
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Reviews
16 reviews so far
100%
saidit'sworth it
94%
saiditworked well
0%
saidit'sa big hassle

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Side effects
12possible side effects
  • Diarrhea
    9%
  • Nausea
    9%
  • Fatigue
    9%
  • Depression
    9%
  • Stuffy or runny nose
    8%
  • Flu or bronchitis
    8%
  • Dizziness
    8%
  • Rash event
    7%
  • Headache
    6%
  • Common cold
    5%
  • Insomnia
    5%
  • Vomiting
    2%
See more detailed side effects
19possible side effects
  • Skin rash
    16%
  • Diarrhea
    14%
  • Pain
    13%
  • Nausea
    10%
  • Dizziness
    9%
  • Itching
    9%
  • Fatigue
    8%
  • Headache
    8%
  • Insomnia
    7%
  • Vomiting
    6%
  • Trouble concentrating
    5%
  • Depression
    5%
  • Indigestion
    4%
  • Anxiety
    4%
  • Abnormal dreams
    3%
  • Abdominal pain
    3%
  • Sleepiness
    2%
  • Nervousness
    2%
  • Loss of appetite
    2%
See more detailed side effects
Risks and risk factors
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Worsening hepatitis B infection
    • Hepatitis B Virus infection
  • Kidney damage
    • History of kidney damage
    • Concurrent use of other drugs known to harm kidneys
  • Bone loss/osteoporosis
    • History of bone fractures
    • Osteoporosis
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Drug resistance while using pre-exposure prophylaxis (PrEP)
    • Undiscovered HIV infection while on PrEP
See more detailed risks and warnings
  • Central nervous system (CNS) effects
    • Starting Sustiva (efavirenz) for the first few weeks.
    • Taking alcohol or other drugs that also affect your nervous system
  • Fat redistribution
    • HIV treatment
  • Liver damage
    • History of liver damage
    • Alcohol intake
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
  • Psychiatric effects
    • History of mental illness
    • History of substance abuse
  • Rash
    • History of severe skin reactions
    • Children
See more detailed risks and warnings