Compare Tylenol vs. Acetaminophen with codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Relieves pain and fever.

Tylenol Regular Strength (acetaminophen) effectively reduces fever and relieves pain, but it doesn't lower inflammation and swelling.

3.7/ 5 average rating with 1002 reviewsforTylenol
Treats mild to moderate pain.

Acetaminophen with codeine (acetaminophen / codeine) is a good option to treat pain when over-the-counter medicines aren't enough, but don't take too much acetaminophen (Tylenol) since it can hurt your liver.

3.7/ 5 average rating with 581 reviewsforAcetaminophen with codeine
Upsides
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin and Advil.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • Tylenol Regular Strength (acetaminophen) has been used for a long time and is generally safe for short-term use.
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relief in a single pill.
  • Provides quick relief for mild to moderate pain.
  • Good for as-needed pain and control.
  • Generally well tolerated, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
Downsides
  • Tylenol Regular Strength (acetaminophen) doesn't treat some kinds of pain as well as other medications like Advil.
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Many people get constipated taking Acetaminophen with codeine (acetaminophen / codeine).
  • All opioid containing medicines have the risk of addiction and withdrawal when used long-term.
  • Acetaminophen (Tylenol) has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful since many over-the-counter medicines also have acetaminophen.
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Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
  • Suppository
  • Injection
  • Pill
  • Liquid
Price
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Reviews
1002 reviews so far
77%
saidit'sworth it
37%
saiditworked well
3%
saidit'sa big hassle

Have you used Tylenol Regular Strength (acetaminophen)?

Leave a review
581 reviews so far
69%
saidit'sworth it
41%
saiditworked well
9%
saidit'sa big hassle

Have you used Acetaminophen with codeine (acetaminophen / codeine)?

Leave a review
Side effects
The Tylenol Regular Strength (acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
The Acetaminophen with codeine (acetaminophen / codeine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Accidental overdose and death
    • Medication administering errors
    • Injection formulation
    • Exceeding the recommended maximum daily limits
  • Liver damage
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
See more detailed risks and warnings
  • Liver failure and death
    • Alcohol use
    • Taking over-the-counter medicines with acetaminophen
    • History of liver disease
  • High risk to children
  • Use with other CNS depressants
    • Use with alcohol
    • Use with benzodiazepines
    • Use with other opiates
  • Severe allergic reaction
See more detailed risks and warnings