Compare Uloric vs. Benemid
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Uloric (febuxostat) is a medication you take once daily for gout, but it takes a few weeks to kick in.
Benemid (probenecid) can be used to lower high uric acid levels in people with gout, but it is not a first-choice treatment because it takes a long time to kick in.
- Uloric (febuxostat) can be used to lower uric acid if Zyloprim (allopurinol) doesn't work.
- You only need to take Uloric (febuxostat) once a day.
- People with mild to moderate kidney disease can use Uloric (febuxostat).
- Benemid (probenecid) is available in generic.
- It can raise levels of certain antibiotics in the body and make those antibiotics work better.
- It is recommended as a second-choice medicine to help lower uric acid levels if they're not going down fast enough.
- You can have more gout attacks in the first few weeks of taking Uloric (febuxostat).
- While taking Uloric (febuxostat), you need to drink a lot of fluids to stop kidney stones from forming.
- You'll have to get your blood checked often with Uloric (febuxostat) therapy.
- Uloric (febuxostat) doesn't come in generic, so it can be more expensive.
- Benemid (probenecid) is not a first-choice treatment for gout because it takes a while to kick in.
- It doesn't work well in people who are using aspirin, or have kidney problems.
- You have to take Benemid (probenecid) 2 times a day. Other stronger drugs for gout are only taken 1 time a day.
- Gout flare-ups
- Blood clots
- History of stroke or heart attack
- Liver problems
- Allergic reaction
- History of skin reaction to allopurinol
- Kidney stones
- Blood disorders
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Gout attacks
- Taking Benemid (probenecid) for the first few weeks
- Kidney problems
- History of kidney problems
- Stomach ulcers
- History of esophagus or stomach problems, including ulcers