Compare Unisom vs. Lunesta

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Lunesta (Eszopiclone)

Prescription only
Treats allergy symptoms and helps you sleep.

Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.

3.3/ 5 average rating with 585 reviewsforUnisom
Helps you sleep.

Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.

3.3/ 5 average rating with 592 reviewsforLunesta
  • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
  • Has fewer side effects than prescription sleep aid medications.
  • Available over the counter without a prescription.
  • Not habit-forming like other sleep aids can be.
  • Effective at helping people fall asleep faster and sleep longer.
  • Not as habit-forming, so you can use it for longer than most other sleep medicines.
  • Shouldn't be used unless you have a full night to sleep.
  • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
  • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
  • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
  • More likely to cause withdrawal symptoms if you stop taking it suddenly.
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
  • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
No pricing information available
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585 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Unisom Sleeptabs (Doxylamine)?

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592 reviews so far
saidit'sworth it
saiditworked well
saidit'sa big hassle

Have you used Lunesta (Eszopiclone)?

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Side effects
The Unisom Sleeptabs (Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Headache
  • Unpleasant Taste
  • Dyspepsia
  • Pain
  • Diarrhea
  • Pruritus
  • Dry Mouth
  • Abnormal Dreams
  • Neuralgia
  • Urinary Tract Infection
See more detailed side effects
Risks and risk factors
  • Overdosage
    • Using other drugs with similar ingredients
  • Increased side effects
    • Age 65 years or older
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Hyperactivity
    • Children age 6 years or younger
  • Trouble urinating
    • Enlarged prostate
    • History of bladder problems
  • Vision changes
    • Glaucoma
  • Breastfeeding
    • Nursing mothers
See more detailed risks and warnings
  • Dependence and withdrawal
    • Continuous use for 2 weeks or more
  • Driving impairment
    • Alcohol
    • Taking other medicines that make you less alert
    • Less than 7 hours of sleep.
  • Abnormal thoughts
    • Undiagnosed psychiatric conditions
  • Sleep driving
    • Taking with alcohol or drugs that acts in the brain
  • Serious allergic reactions
  • Risk of falls and injury
    • Elderly
    • Higher dose
    • Liver problems
    • Taking Lunesta (Eszopiclone) with other nervous system depressants
    • Long-term use
  • Risk to fetus
    • Women of childbearing age
    • Breast-feeding
See more detailed risks and warnings