Compare Unisom vs. Nyquil Cold And Flu
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Treats allergy symptoms and helps you sleep.
Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.
●●●●●
3.3/ 5 average rating with 585 reviewsforUnisom
Relieves cold and flu symptoms, and helps you sleep.
Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
●●●●●
3.8/ 5 average rating with 1188 reviewsforNyquil Cold And Flu
Upsides
- Works well to help you fall asleep and doesn't make you feel groggy the next morning.
- Has fewer side effects than prescription sleep aid medications.
- Available over the counter without a prescription.
- Not habit-forming like other sleep aids can be.
- Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
- The cough medicine (dextromethorphan) works well and has very few side effects.
- The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
- The antihistamine (doxylamine) will help you sleep.
Downsides
- Shouldn't be used unless you have a full night to sleep.
- You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
- Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
- It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
- If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
- You shouldn't use it if you have high blood pressure.
- To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Used for
Dosage forms
- Pill
- Chewable tablet
- Liquid
- Pill
- Liquid
Price
Lowest price
$7.11
Find instant savings near youLowest price
$11.31
Find instant savings near youWant to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
Reviews
585 reviews so far
58%
saidit'sworth it
32%
saiditworked well
11%
saidit'sa big hassle
Have you used Unisom Sleeptabs (Doxylamine)?
Leave a review1188 reviews so far
83%
saidit'sworth it
42%
saiditworked well
7%
saidit'sa big hassle
Have you used Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)?
Leave a reviewSide effects
The Unisom Sleeptabs (Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
The Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
- Overdosage
- Using other drugs with similar ingredients
- Increased side effects
- Age 65 years or older
- Driving impairment
- Taking with alcohol
- Taking other medicines that make you less alert
- Hyperactivity
- Children age 6 years or younger
- Trouble urinating
- Enlarged prostate
- History of bladder problems
- Vision changes
- Glaucoma
- Breastfeeding
- Nursing mothers
- Liver damage
- Drinking more than 2 alcoholic beverages a day
- Taking with other Tylenol-containing medicines
- History of liver disease
- Serotonin syndrome
- Using other medications that affect serotonin
- Driving impairment
- Taking with alcohol
- Taking with other medicines that make you less alert
- Antihistamine side effects
- Age 65 years or older
- Glaucoma
- Benign prostatic hypertrophy (BPH)