Compare Vancocin vs. Cleocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Treats bacterial infections.

Vancocin (vancomycin) is effective in treating C. difficile-associated diarrhea or Staph infection of the small intestine and colon.

Topical treatment for acne.

Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.

3.5/ 5 average rating with 115 reviewsforCleocin
Upsides
  • Vancocin (vancomycin) is the first choice medicine to treat C. difficile-associated diarrhea.
  • Available in generic.
  • Available as both a capsule and a liquid.
  • Available in generic.
  • Topical form treats acne.
  • Available in different oral forms: tablet, capsule, and suspension.
  • Available in forms to treat skin infections and vaginal infections.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Can be taken with or without food.
Downsides
  • Vancocin (vancomycin) is only given by mouth to treat C. difficile-associated diarrhea or Staph infection of the small intestine and colon. It is not effective for other types of infections.
  • Vancocin (vancomycin) must be taken 3 to 4 times a day.
  • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
  • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
  • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
  • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
  • If you're taking the topical form, it can cause sensitivity and irritation.
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Used for
  • Clostridium difficile diarrhea
  • Staphylococcal infection of small intestine and colon
Dosage forms
  • Pill
  • Liquid
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
Price
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Reviews
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115 reviews so far
57%
saidit'sworth it
43%
saiditworked well
19%
saidit'sa big hassle

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Side effects
13possible side effects
  • Nausea
    17%
  • Abdominal pain
    15%
  • Low potassium levels
    13%
  • Vomiting
    9%
  • Diarrhea
    9%
  • Fever
    9%
  • Gas
    8%
  • Urinary tract infection
    8%
  • Headache
    7%
  • Swelling
    6%
  • Back pain
    6%
  • Fatigue
    5%
  • Kidney problems
    5%
See more detailed side effects
The Cleocin T (Clindamycin Phosphate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Oral use only
  • Kidney problems
    • Age 65 and older
    • Kidney problems
    • Kidney disease
    • Hemodialysis
  • New infection
  • Hearing loss
    • Underlying hearing loss
    • Taking high doses of Vancocin (vancomycin) intravenously
    • Using another medicine that causes hearing loss
See more detailed risks and warnings
  • Diarrhea
  • Liver damage
    • History of liver disease
  • Rash
See more detailed risks and warnings