Compare Vantin vs. penicillin

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Vantin (cefpodoxime)

Prescription only
Treats bacterial infections.

Vantin (cefpodoxime) is good for treating many bacterial infections and it works best if you take the full course without stopping.

Treats bacterial infections.

Penicillin VK (penicillin) is good at treating strep throat and is cheap, however, it can only be used for certain infections as many bacteria have developed resistance to it.

3.9/ 5 average rating with 1297 reviewsforpenicillin
  • Used to treat many types of bacterial infections.
  • Available in two different forms: tablet and liquid suspension.
  • People usually have few side effects when taking it.
  • Vantin (cefpodoxime) is available as a generic.
  • The suspension may be taken with or without food.
  • Compared to alternatives, Penicillin VK (penicillin) is the preferred choice for treating strep throat infections.
  • This medicine is available as a generic, which is cheap.
  • It’s also available in different forms: pill and liquid.
  • If you're on blood thinners, let your doctor know. Vantin (cefpodoxime) can interact with your medications and make you more likely to bleed.
  • You can't take antacids within 2 hours of this drug.
  • Vantin (cefpodoxime) can affect certain lab tests, let all your healthcare providers know that you're taking Vantin (cefpodoxime).
  • Many bacteria are resistant to Penicillin VK (penicillin), so it only works for certain infection typically in ear, nose, and throat.
  • Penicillin VK (penicillin) has a bitter taste. Children might not like the taste.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
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Side effects
5possible side effects
  • Diarrhea
  • Nausea
  • Diaper rash/fungal skin rash
  • Other skin rashes
  • Vomiting
See more detailed side effects
The Penicillin VK (penicillin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Diarrhea
  • Allergic reaction
    • Allergy to antibiotics
  • New infection
    • Taking Vantin (cefpodoxime) for a long time
  • Kidney problems
    • Kidney problems
    • Kidney disease
    • Hemodialysis
See more detailed risks and warnings
  • Diarrhea
    • Taking Penicillin VK (penicillin) for a long time
  • Interaction with birth control pills
  • Allergic reaction
    • History of severe allergic reaction to Penicillin VK (penicillin)
    • Cephalosporin medication allergy
See more detailed risks and warnings