Compare Velcade vs. Revlimid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats mantle cell lymphoma and multiple myeloma.

Velcade (bortezomib) is a first-choice treatment for multiple myeloma and an effective option for mantle cell lymphoma. However, it frequently causes burning, tingling, and numbness in the hands and feet.

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  • Velcade (bortezomib) improved response and delayed cancer progression in multiple myeloma and mantle cell lymphoma.
  • First-choice treatment for multiple myeloma, and effective treatment for mantle cell lymphoma.
  • Can administer Velcade (bortezomib) on your own at home, after the doctor shows you how.
  • Compared to some other chemotherapy treatments, Velcade (bortezomib) causes less nausea and vomiting.
  • Giving this medicine subcutaneously decreases side effects compared to intravenously.
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  • Can worsen heart, nerve, and liver conditions.
  • Usually need to take in combination with other cancer medicines.
  • Because of the risk of harm during pregnancy, you need to take use contraception during treatment and for 2 months after treatment ends.
  • People with diabetes will have to check their blood sugar more frequently while taking Velcade (bortezomib).
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Used for
  • Mantle cell lymphoma
  • Relapse or progression after 2 prior therapies
  • 1 of which included bortezomib Multiple myeloma
  • In combination with dexamethasone
  • In patients who have received at least 1 prior therapy Myelodysplastic syndrome
  • Transfusion-dependent
  • Deletion 5q abnormality
  • Low or intermediate-1 risk
  • Chronic lymphoid leukemia
  • Relapsed or refractory Multiple myeloma
  • In combination with dexamethasone
  • First-line therapy Myelofibrosis Non-Hodgkin's lymphoma
  • Aggressive disease
  • Relapsed or refractory
Dosage forms
  • Injection
  • Pill
No pricing information available
No pricing information available
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Side effects
12possible side effects
  • Burning or prickling sensation in limbs
  • Low platelets
  • Diarrhea
  • Nausea
  • Low white blood cells (neutrophils)
  • Neuropathic pain
  • Low red blood cells
  • Low white blood cells (leukocytes)
  • Vomiting
  • Fever
  • Weakness
  • Fatigue
See more detailed side effects
The Revlimid (Lenalidomide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Tingling or numbness in arms or legs
    • Existing peripheral neuropathy (numbness, pain, or burning feeling in feet or hands)
  • Low blood pressure
    • History of fainting
    • Taking medicines that cause low blood pressure
    • Dehydration
  • Heart damage
    • History of heart failure
    • Obesity
    • High cholesterol
    • Diabetes
  • Lung damage
  • Stomach upset
  • Low blood cell counts
See more detailed risks and warnings
No information currently available