Compare Videx vs. Baraclude

Head-to-head comparisons of medication uses, side effects, ratings, and more.


Videx (didanosine)

Prescription only

Baraclude (entecavir)

Prescription only
Works with other medicines to treat HIV infection.

Videx (didanosine) is not a first-choice treatment for HIV because there are newer medications that work well and are easier to take. However, Videx (didanosine) can be an option if other HIV medications haven't worked for you.

Treats hepatitis B.

Baraclude (entecavir) works well to treat hepatitis B, but tenofovir (Viread or Vemlidy) might be the better choice if you’ve taken other oral medicines for hepatitis B before or also have HIV.

  • Videx (didanosine) is available in pill or liquid form.
  • Videx (didanosine) can be used in children 2 weeks of age and older.
  • Videx (didanosine) can be taken either once or twice daily.
  • Baraclude (entecavir) is a first-choice medicine to treat hepatitis B.
  • Safer option for people with kidney damage.
  • Side effects are mild and short-lived.
  • Can be used in children as young as 2 years old.
  • Conveniently comes as a liquid for children and people who struggle to swallow pills.
  • Videx (didanosine) cannot be taken by itself. It must be used with other HIV medications to treat HIV.
  • People commonly experience side effects such as diarrhea, nerve pain, and nausea when taking Videx (didanosine).
  • Videx (didanosine) should be used with caution if you have liver or kidney issues.
  • Videx (didanosine) shouldn't be taken with allopurinol or ribavirin. If you are taking these medicines, let your doctor know.
  • Doesn't cure hepatitis B.
  • Might not be a good choice for people who’ve taken Epivir HBV (lamivudine) in the past due to the possibility of resistance.
  • Not the first choice for people with both hepatitis B and HIV.
Used for
  • Hepatitis B
  • Prevention of hepatitis B reinfection after liver transplant
Dosage forms
  • Delayed release Pill
  • Liquid
  • Pill
  • Liquid
No pricing information available
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Side effects
6possible side effects
  • Diarrhea
  • Nerve pain
  • Nausea
  • Headache
  • Rash
  • Vomiting
See more detailed side effects
2possible side effects
  • Headache
  • Tiredness
See more detailed side effects
Risks and risk factors
  • Pancreatitis
    • History of pancreatic issues
    • Alcohol consumption
    • Concomitant use with Zerit (stavudine)
    • Kidney problems
  • Lactic acidosis & severe liver damage
  • Nerve pain
    • Advanced HIV disease
    • History of peripheral neuropathy
    • Taking other medications that also cause peripheral neuropathy
  • Retinal changes
  • Fat redistribution
    • HIV treatment
  • Immune reconstitution syndrome
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy
See more detailed risks and warnings
  • Worsening of hepatitis B infection
    • Stopping Baraclude (entecavir)
  • Hepatitis B and HIV co-infection
    • HIV infection
  • Buildup of acid in the blood and swollen, fatty liver
    • Obesity
    • History of liver disease
    • Women
    • Taking Baraclude (entecavir) for a long time
See more detailed risks and warnings