Compare Viibryd vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Viibryd (vilazodone)

Prescription only

Oleptro (Trazodone)

Prescription only
Treats depression.

Viibryd (vilazodone) is a good option to treat depression, but you can cause stomach irritation including diarrhea.

4.0/ 5 average rating with 95 reviewsforViibryd
Improves mood and helps you sleep.

Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.

3.6/ 5 average rating with 59 reviewsforOleptro
Upsides
  • Viibryd (vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (vilazodone) doesn't need to be changed if you have kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and less sexual side effects.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides
  • It may take several weeks before you feel the full effects of Viibryd (vilazodone).
  • Cannot take Viibryd (vilazodone) if you have severe liver problems.
  • Cannot take Viibryd (vilazodone) with other medicines called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (vilazodone).
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
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Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
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Reviews
95 reviews so far
67%
saidit'sworth it
63%
saiditworked well
13%
saidit'sa big hassle

Have you used Viibryd (vilazodone)?

Leave a review
59 reviews so far
73%
saidit'sworth it
49%
saiditworked well
24%
saidit'sa big hassle

Have you used Oleptro (Trazodone)?

Leave a review
Side effects
24possible side effects
  • Diarrhea
    28%
  • Nausea
    24%
  • Headache
    14%
  • Dizziness
    8%
  • Dry mouth
    7%
  • Loss of sleep
    6%
  • Vomiting
    5%
  • Sleepiness
    5%
  • Abdominal pain
    4%
  • Low sex drive (males)
    4%
  • Upset stomach
    3%
  • Gas
    3%
  • Abnormal dreams
    3%
  • Restlessness
    3%
  • Fatigue
    3%
  • Increased appetite
    3%
  • Erectile dysfunction (males)
    3%
  • Stomach infection
    2%
  • Tingling and numbness
    2%
  • Palpitations
    2%
  • Increased weight
    2%
  • Abnormal orgasm (males)
    2%
  • Ejaculation disorder (males)
    2%
  • Low sex drive (females)
    2%
See more detailed side effects
29possible side effects
  • Somnolence/Sedation
    46%
  • Drowsiness
    41%
  • Dry Mouth
    34%
  • Headache
    33%
  • Dizziness/Lightheadedness
    28%
  • Dry mouth
    25%
  • Dizziness
    25%
  • Nausea
    21%
  • Blurred Vision
    15%
  • Fatigue
    15%
  • Nausea/Vomiting
    13%
  • Diarrhea
    9%
  • Constipation
    8%
  • Skin Condition/Edema
    7%
  • Weight Loss
    6%
  • Nasal/Sinus Congestion
    6%
  • Abdominal/Gastric Disorder
    6%
  • Syncope
    5%
  • Musculoskeletal Aches/Pains
    5%
  • Tremors
    5%
  • Nightmares/Vivid Dreams
    5%
  • Weight Gain
    5%
  • Back pain
    5%
  • Vision blurred
    5%
  • Sexual dysfunction
    5%
  • Hypotension
    4%
  • Incoordination
    2%
  • Ejaculation disorders
    2%
  • Decreased libido
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Antidepressants
    • Lithium
    • Triptans
    • St. John's wort
    • Fentanyl
    • Tramadol
    • MAO inhibitors
  • Abnormal bleeding
    • Taking Viibryd (vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting
  • Low sodium levels in the blood
    • Elderly
    • Taking with diuretic medications
  • Eye problems
    • Glaucoma
  • Activation of mania/hypomania
    • History of bipolar disorder (mixed/mania)
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Seizures
    • History of seizures
    • Alcoholism
    • Eating disorder
    • Higher dose
    • Drug interactions
  • Painful erection
  • Low blood pressure
    • Age 65 years or older
  • Driving impairment
    • Alcohol
    • Taking other medicines that make you less alert
See more detailed risks and warnings