Compare Viread vs. Baraclude

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Works with other medicines to treat HIV infection. Also treats Hepatitis B Virus.

Viread (tenofovir) is a first-line choice to be used in combination with other medications to treat HIV. Viread (tenofovir) is also a first-line choice in treating HBV.

Treats hepatitis B.

Baraclude (entecavir) works well to treat hepatitis B, but tenofovir (Viread or Vemlidy) might be the better choice if you’ve taken other oral medicines for hepatitis B before or also have HIV.

Upsides
  • Can be used with other medications to prevent HIV infection after an exposure.
  • Taken only once daily, with or without food.
  • There are newer formulations of Viread (tenofovir) available that are safer on your kidneys.
  • If tablets are hard for you to swallow, Viread (tenofovir) is available in a powder that's mixed with soft foods.
  • Baraclude (entecavir) is a first-choice medicine to treat hepatitis B.
  • Safer option for people with kidney damage.
  • Side effects are mild and short-lived.
  • Can be used in children as young as 2 years old.
  • Conveniently comes as a liquid for children and people who struggle to swallow pills.
Downsides
  • Viread (tenofovir) can't be used on its own to treat HIV infection.
  • Not recommended for patients with kidney damage.
  • Can weaken your bones.
  • Might worsen hepatitis B infections if you suddenly stop taking it.
  • Doesn't cure hepatitis B.
  • Might not be a good choice for people who’ve taken Epivir HBV (lamivudine) in the past due to the possibility of resistance.
  • Not the first choice for people with both hepatitis B and HIV.
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Used for
  • Hepatitis B
  • Prevention of hepatitis B reinfection after liver transplant
Dosage forms
  • Pill
  • Powder
  • Pill
  • Liquid
Price
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Reviews
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Side effects
1possible side effects
  • Nausea
    9%
See more detailed side effects
2possible side effects
  • Headache
    4%
  • Tiredness
    3%
See more detailed side effects
Risks and risk factors
  • Lactic acidosis | Enlarged, fatty liver
    • Liver disease
    • Women
    • Obesity
  • Cannot be used to treat Hepatitis B Virus (HBV)
    • Hepatitis B Virus infection
  • Mood and behavior changes
    • History of mental illness
  • Decreased bone mineral density
    • History of bone fractures
    • Osteoporosis
  • Kidney damage
    • History of kidney damage
    • Concurrent use of other drugs known to harm kidneys
  • Hypersensitivity (allergic) reactions
    • Prior severe allergic reaction to Viread (tenofovir) or any of its individual drug components.
See more detailed risks and warnings
  • Worsening of hepatitis B infection
    • Stopping Baraclude (entecavir)
  • Hepatitis B and HIV co-infection
    • HIV infection
  • Buildup of acid in the blood and swollen, fatty liver
    • Obesity
    • History of liver disease
    • Women
    • Taking Baraclude (entecavir) for a long time
See more detailed risks and warnings